A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china.

A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china.
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DOI:
10.18632/oncotarget.17599
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发表时间:
2017-09-22
期刊:
影响因子:
--
通讯作者:
Qiao YL
Qiao YL
中科院分区:
其他
文献类型:
--
作者:
Fan JH;Zhang YQ;Shi SS;Chen YJ;Yuan XH;Jiang LM;Wang SM;Ma L;He YT;Feng CY;Sun XB;Liu Q;Deloso K;Chi Y;Qiao YL

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关于亚洲患者胃肠胰神经内分泌肿瘤(GEP-NEN)的代表性数据很少,尤其是在中国。本研究旨在创建中国患者的 GEP-NEN 档案。这是一项以医院为基础、全国性、多中心的10年(2001-2010)回顾性研究,收集了三级转诊医院的GEP-NEN患者信息。所选医院中所有 2010 年病理确诊的住院 GEP-NEN 病例均纳入其中。测量了主要的GEP-NEN位点,并比较了每个肿瘤位点的流行病学和临床信息。 GEP-NEN 最常见的原发部位是胰腺(31.5%)和直肠(29.6%),其次是贲门(11.6%)和胃体(15.4%)。小肠和结肠 NEN 在所有患者中所占比例相对较小。胰腺和直肠NENs较心脏和胃体NENs多见于年轻(P<0.001)、女性(P<0.001)、城市(P<0.001)、文化程度较高(P=0.032)的居民,且诊断较早(P<0.001)和较低级别(P<0.001)。手术仍然是所有组中的主要治疗方法。有必要对 GEP-NEN 的共性和异质性进行更多研究,以提高诊断效率和治疗结果。
Representative data on the gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) in Asian patients is rare, especially in China. This study aims to create a GEP-NENs profile of Chinese patients. This was a hospital-based, nation-wide, and multi-center 10-year (2001-2010) retrospective study which collected GEP-NEN patients’ information in tertiary referral hospitals. All 2010 inpatient GEP-NEN cases with confirmed pathology in the selected hospitals were included. The primary GEP-NEN sites were measured and the epidemiological and clinical information of each tumor site were compared. The most common primary sites for GEP-NEN were the pancreas (31.5%) and rectum (29.6%), followed by the cardia (11.6%) and body (15.4%) of stomach. Small intestinal and colonic NENs took up a relatively small proportion of all patients. Pancreatic and rectal NENs, rather than cardiac and gastric body NENs, tended to be found in younger (P<0.001), female (P<0.001), urban (P<0.001) residents with a higher education level (P=0.032) and were also diagnosed at earlier stage (P<0.001) and lower grade (P<0.001). Surgery remained the primary treatment method in all groups. More studies on the commonality and heterogeneity of GEP-NENs are warranted to improve diagnosis efficiencies and treatment outcomes.
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