Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms.
Flow residence time and regions of intraluminal thrombus deposition in intracranial aneurysms.
复制标题
DOI：
10.1007/s10439-010-0065-8
复制
发表时间：
2010-10
影响因子：
3.8
通讯作者：
Saloner, D.
中科院分区：
文献类型：
--
作者：
Rayz, V. L.;Boussel, L.;Ge, L.;Leach, J. R.;Martin, A. J.;Lawton, M. T.;McCulloch, C.;Saloner, D.
关键词：
颅内动脉瘤中的血栓形成，虽然有时会稳定病变生长，但可能存在额外的血栓栓塞风险。血流动力学在恶性疾病进展中的作用可以通过患者特异性计算建模来阐明。在我们之前的工作中，根据3例梭形基底动脉瘤患者的MRI数据构建了患者特定的计算流体动力学（CFD）模型，这些患者无血栓，然后继续发展管腔内血栓。在这项研究中，我们研究了增加流动停留时间（RT）的影响，通过模拟被动标量平流在相同的空间几何形状。非牛顿脉动流模拟进行了基线的几何形状和一个新的后处理技术，被称为“虚拟墨水”和被动标量分布图的基础上，被用来可视化的流量和估计流量RT。虚拟墨水技术清楚地描绘了流动分离的区域。在邻近血管壁的不同位置处的流动RT被计算为虚拟墨水标量保持在阈值以上的时间。然后将不同区域获得的RT值与随访MR研究中观察到的颅内血栓位置相关。对于每名患者，壁面剪切应力（WSS）分布也从CFD模拟中获得，并与血栓位置相关。相关性分析确定了CFD预测RT增加或WSS降低的区域与观察到体内发生血栓沉积的区域之间的显著关系。包括低WSS和增加RT的模型预测血栓易发区显著优于仅RT或WSS的模型。
Thrombus formation in intracranial aneurysms, while sometimes stabilizing lesion growth, can present additional risk of thrombo-embolism. The role of hemodynamics in the progression of aneurysmal disease can be elucidated by patient-specific computational modeling. In our previous work, patient-specific computational fluid dynamics (CFD) models were constructed from MRI data for three patients who had fusiform basilar aneurysms that were thrombus-free and then proceeded to develop intraluminal thrombus. In this study, we investigated the effect of increased flow residence time (RT) by modeling passive scalar advection in the same aneurysmal geometries. Non-Newtonian pulsatile flow simulations were carried out in base-line geometries and a new postprocessing technique, referred to as “virtual ink” and based on the passive scalar distribution maps, was used to visualize the flow and estimate the flow RT. The virtual ink technique clearly depicted regions of flow separation. The flow RT at different locations adjacent to aneurysmal walls was calculated as the time the virtual ink scalar remained above a threshold value. The RT values obtained in different areas were then correlated with the location of intra-aneurysmal thrombus observed at a follow-up MR study. For each patient, the wall shear stress (WSS) distribution was also obtained from CFD simulations and correlated with thrombus location. The correlation analysis determined a significant relationship between regions where CFD predicted either an increased RT or low WSS and the regions where thrombus deposition was observed to occur in vivo. A model including both low WSS and increased RT predicted thrombus-prone regions significantly better than the models with RT or WSS alone.
登录
查看更多内容
影响因子：
3.3
作者：
Jesty, J;Yin, W;Bluestein, D
通讯作者：
Bluestein, D
影响因子：
8.3
作者：
Shojima, M;Oshima, M;Kirino, T
通讯作者：
Kirino, T
DOI：
10.1115/1.2895545
发表时间：
1993-11-01
影响因子：
1.7
作者：
GIDDENS, DP;ZARINS, CK;GLAGOV, S
通讯作者：
GLAGOV, S
影响因子：
2.4
作者：
RAMSTACK, JM;ZUCKERMAN, L;MOCKROS, LF
通讯作者：
MOCKROS, LF
DOI：
10.1115/1.2795954
发表时间：
1996-05-01
影响因子：
1.7
作者：
Kunov, MJ;Steinman, DA;Ethier, CR
通讯作者：
Ethier, CR