A study of pyrimidine base damage in relation to oxidative stress and cancer.
A study of pyrimidine base damage in relation to oxidative stress and cancer.
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DOI：
10.1038/sj.bjc.6605176
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发表时间：
2009-08-04
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
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一个由来已久的假设是，氧化应激是癌症的风险因素。与健康对照组相比，癌症患者白细胞DNA中的氧化损伤水平更高，这支持了这一假设。两种通常被忽视的DNA损伤类型，甲酰胺修饰和胸腺嘧啶乙二醇修饰，都来自嘧啶碱基，被检测为氧化应激的标志。检测卵巢癌患者和健康对照组外周血白细胞DNA损伤水平。卵巢癌患者的这两种修饰水平都高于健康对照组，尽管在甲酰胺修饰的情况下，年龄不能被排除为一个因素。我们的结果与其他已发表的氧化DNA损伤测量相结合，支持了癌症患者白细胞平均氧化损伤高于健康对照组的假设。
A long-standing hypothesis is that oxidative stress is a risk factor for cancer. Support for this hypothesis comes from observations of higher levels of oxidative damage in the DNA of WBC of cancer patients compared with healthy controls. Two generally overlooked types of DNA damage, the formamide modification and the thymine glycol modification, both derived from pyrimidine bases, were assayed as markers of oxidative stress. Damage levels were measured in the DNA of WBC of ovarian cancer patients and of healthy controls. The levels of both modifications were higher in ovarian cancer patients than in healthy controls although in the case of the formamide modification age could not be ruled out as a factor. Our results in combination with other published measurements of oxidative DNA damage support the hypothesis that oxidative damage, on average, is higher in WBC of cancer patients than in healthy controls.
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影响因子：
6.4
作者：
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通讯作者：
Olinski, R
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Vaughan, N
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Sáez, GT