Blood and interstitial flow in the hierarchical pore space architecture of bone tissue.
Blood and interstitial flow in the hierarchical pore space architecture of bone tissue.
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DOI：
10.1016/j.jbiomech.2014.12.013
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发表时间：
2015-03-18
影响因子：
2.4
通讯作者：
Cardoso, Luis
中科院分区：
文献类型：
--
作者：
Cowin, Stephen C.;Cardoso, Luis
骨组织中有两种主要类型的流体，血液和间质液。这些液体的化学成分随时间和骨骼中的位置而变化。血液通过含有氧气和其他营养物质的动脉系统到达，血液成分通过含有较少氧气和减少营养的静脉系统离开。在骨内，如同在其他组织内一样，物质从血液通过动脉壁进入间质液。间质液的运动将这些物质带到骨内的细胞，同时从细胞中带走废物。没有这些流体运动，骨组织就无法存活。本文综述了具有分级孔隙结构的多孔弹性材料模型的发展，该模型用于描述活骨组织中的血流和间质液流动。该模型适用于确定血管孔隙度和骨组织中的腔隙-小管孔隙度之间的孔隙流体交换的问题，由于循环机械载荷和血压。这些结果对于理解骨组织中的间质流是基本的，而间质流又是理解从脉管系统到埋藏在骨组织中的骨细胞的营养转运以及这些细胞的机械转导过程的基本。
There are two main types of fluid in bone tissue, blood and interstitial fluid. The chemical composition of these fluids varies with time and location in bone. Blood arrives through the arterial system containing oxygen and other nutrients and the blood components depart via the venous system containing less oxygen and reduced nutrition. Within the bone, as within other tissues, substances pass from the blood through the arterial walls into the interstitial fluid. The movement of the interstitial fluid carries these substances to the cells within the bone and, at the same time, carries off the waste materials from the cells. Bone tissue would not live without these fluid movements. The development of a model for poroelastic materials with hierarchical pore space architecture for the description of blood flow and interstitial fluid flow in living bone tissue is reviewed. The model is applied to the problem of determining the exchange of pore fluid between the vascular porosity and the lacunar-canalicular porosity in bone tissue due to cyclic mechanical loading and blood pressure. These results are basic to the understanding of interstitial flow in bone tissue that, in turn, is basic to understanding of nutrient transport from the vasculature to the bone cells buried in the bone tissue and to the process of mechanotransduction by these cells.
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DOI：
10.1302/0301-620x.65b5.6643563
发表时间：
1983-01-01
影响因子：
--
作者：
AGLIETTI, P;INSALL, JN;DESCHAMPS, G
通讯作者：
DESCHAMPS, G
影响因子：
4
作者：
Bagger, Y. Z.;Rasmussen, H. B.;Alexandersen, P.;Werge, T.;Christiansen, C.;Tanko, L. B.
通讯作者：
Tanko, L. B.
影响因子：
4.1
作者：
BURKHARDT, R;KETTNER, G;GILG, T
通讯作者：
GILG, T
影响因子：
3.5
作者：
Benalla, M.;Cardoso, L.;Cowin, S. C.
通讯作者：
Cowin, S. C.
影响因子：
4.2
作者：
Adami, S;Braga, V;Battaglia, E
通讯作者：
Battaglia, E