Impact of COVID-19 on Alzheimer's Disease Risk: Viewpoint for Research Action.

Impact of COVID-19 on Alzheimer's Disease Risk: Viewpoint for Research Action.
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DOI:
10.3390/healthcare8030286
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发表时间:
2020-08-21
期刊:
Healthcare (Basel, Switzerland)
影响因子:
--
通讯作者:
Uberti D
Uberti D
中科院分区:
其他
文献类型:
--
作者:
Abate G;Memo M;Uberti D

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在冠状病毒病19(COVID-19)爆发期间,科学界的主要努力都集中在确定有效的药物治疗方法以治愈急性严重症状和开发可靠的疫苗上。另一方面,我们不能排除在严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)阳性受试者中,病毒感染可能会产生长期后果,导致痴呆和神经退行性疾病等慢性疾病。考虑到SARS-CoV-2感染受试者的年龄,神经侵袭潜力可能导致/促成神经退行性疾病的发展。在这里,我们分析了SARS-CoV-2感染和阿尔茨海默病风险之间的可能联系,并在疾病发展的基础上假设了可能的机制。这一反思提出了今天就开始实验性研究阿尔茨海默病(AD)和COVID-19之间的机制联系的必要性,以便明天做好准备。
In the middle of the coronavirus disease 19 (COVID-19) outbreak, the main efforts of the scientific community are rightly all focused on identifying efficient pharmacological treatments to cure the acute severe symptoms and developing a reliable vaccine. On the other hand, we cannot exclude that, in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) positive subjects, the virus infection could have long-term consequences, leading to chronic medical conditions such as dementia and neurodegenerative disease. Considering the age of SARS-CoV-2 infected subjects, the neuroinvasive potential might lead/contribute to the development of neurodegenerative diseases. Here, we analyzed a possible link between SARS-CoV-2 infection and Alzheimer’s disease risk, hypothesizing possible mechanisms at the base of disease development. This reflection raises the need to start to experimentally investigating today the mechanistic link between Alzheimer’s disease (AD) and COVID-19 to be ready tomorrow.
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