An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats.
An NMDA antagonist in the MPOA impairs copulation and stimulus sensitization in male rats.
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DOI：
10.1037/a0026460
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发表时间：
2012-02
影响因子：
1.9
通讯作者：
Hull, Elaine M.
中科院分区：
文献类型：
--
作者：
Vigdorchik, Anna V.;Parrish, Bradley P.;Lagoda, Gwen A.;McHenry, Jenna A.;Hull, Elaine M.
全身注射 NMDA 拮抗剂已被证明会损害雄性大鼠的交配。谷氨酸及其 NMDA 受体可能有助于交配的部位之一是内侧视前区 (MPOA)，它对男性性行为至关重要。交配期间，尤其是射精时，MPOA 中会释放谷氨酸。我们在此报告，将 NMDA 拮抗剂 MK-801 显微注射到 MPOA 中，会损害未曾经历性行为的雄性以及经验丰富的雄性的交配行为。在对幼稚动物和性经历后的动物进行测试时，药物治疗对幼稚雄性动物产生了更严重的损害。此外，在对接受雌性大鼠进行 7 次非交配暴露之前，每次将 MK-801 显微注射到 MPOA 中，与 aCSF 治疗的动物相比，在第 8 天的无药物测试中会导致交配障碍；他们的行为与没有预先接触过雌性的雄性的行为相似。因此，MPOA 中的 NMDA 受体有助于控制交配和刺激敏化。谷氨酸通过 NMDA 受体发挥作用，调节许多神经功能，包括神经元可塑性。这是首次证明 MPOA 中的类似机制使雄性大鼠对来自雌性的接受刺激变得敏感，从而增强了它们的行为。
Systemic injections of an NMDA antagonist have been shown to impair mating in male rats. One site where glutamate and its NMDA receptors may contribute to mating is the medial preoptic area (MPOA), which is vital for male sexual behavior. Glutamate is released in the MPOA during copulation, and especially at the time of ejaculation. We report here that the NMDA antagonist MK-801, microinjected into the MPOA, impaired copulatory behavior in sexually naïve as well as experienced males. In animals tested both as naïve and after sexual experience, drug treatment produced more profound impairment in naïve males. In addition, MK-801, microinjected into the MPOA before each of 7 noncopulatory exposures to receptive female rats, resulted in copulatory impairments on a drug-free test on day 8, relative to aCSF-treated animals; their behavior was similar to that of males that had not been pre-exposed to females. Therefore, NMDA receptors in the MPOA contribute to the control of copulation and stimulus sensitization. Glutamate, acting via NMDA receptors, regulates many neural functions, including neuronal plasticity. This is the first demonstration that a similar mechanism in the MPOA sensitizes male rats to the stimuli from a receptive female, and thereby enhances their behavior.
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影响因子：
2.5
作者：
DEWSBURY, DA
通讯作者：
DEWSBURY, DA
影响因子：
1.9
作者：
Lagoda, G;Muschamp, JW;Hull, EM
通讯作者：
Hull, EM
影响因子：
4.7
作者：
Delint-Ramirez, Ilse;Salcedo-Tello, Pamela;Bermudez-Rattoni, Federico
通讯作者：
Bermudez-Rattoni, Federico
DOI：
10.1016/s0163-1047(80)91503-4
发表时间：
1980-01-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
LISK, RD;HEIMANN, J
通讯作者：
HEIMANN, J
影响因子：
2.9
作者：
GILBERT, ME;MACK, CM
通讯作者：
MACK, CM