Frailty and cognitive impairment as predictors of mortality in older Mexican Americans.
Frailty and cognitive impairment as predictors of mortality in older Mexican Americans.
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脆弱和认知障碍是老年墨西哥裔美国人死亡率的预测因素。
DOI：
10.1007/s12603-011-0104-7
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发表时间：
2012-02
影响因子：
5.8
通讯作者：
Ottenbacher, K. J.
中科院分区：
文献类型：
--
作者：
Cano, C.;Samper-Ternent, R.;Al Snih, S.;Markides, K.;Ottenbacher, K. J.
在选定的墨西哥裔美国老年人样本中，检查虚弱和认知障碍之间的关联，作为10年内死亡率的预测因素。使用西班牙裔老年人流行病学研究（1995-96/2004-05）既定人群数据进行纵向分析。西南部的五个州：得克萨斯州、新墨西哥州、科罗拉多、亚利桑那州和加州。67岁及以上的墨西哥裔美国人，虚弱指数和简易精神状态检查（MMSE）的完整信息（n= 1，815）。通过MMSE评分< 21确定的认知障碍。虚弱定义为以下三个或三个以上组成部分：1）体重减轻，2）虚弱，3）自我报告的疲惫，4）缓慢的步行速度，和5）低体力活动水平。社会人口学特征和慢性疾病作为协变量。死亡率是使用国家死亡指数或通过代理确定的。随着MMSE评分随着时间的推移而下降，虚弱个体的百分比以线性方式增加。在控制所有协变量后，虚弱和认知障碍是死亡的独立风险因素（HR 2.03 95% CI 1.57-2.62; HR 1.26 95% CI 1.05-1.52）。当认知障碍和虚弱都被添加到模型中时，认知障碍个体的HR不再具有统计学显著性。在这一人群中，虚弱和认知障碍之间的关系需要仔细分析，以确定增加死亡率和降低生活质量的途径。我们的研究结果表明，与认知障碍相比，虚弱是老年墨西哥裔美国人死亡率的更强预测因素。
Examine the association between frailty and cognitive impairment as predictors of mortality over a 10-year period in a selected sample of older Mexican Americans. Longitudinal analyses using data from the Hispanic Established Populations for the Epidemiologic Study of the Elderly (1995–96/2004–05). Five southwestern states: Texas, New Mexico, Colorado, Arizona, and California. Mexican Americans aged 67 and older with complete information on the frailty index and the Mini Mental State Examination (MMSE) (n=1,815). Cognitive impairment determined by a score in the MMSE < 21. Frailty defined as three or more of the following components: 1) weight-loss, 2) weakness, 3) self-reported exhaustion, 4) slow walking speed, and 5) low physical activity level. Sociodemographic characteristics and chronic medical conditions were used as covariates. Mortality was determined using the National Death Index or by proxy. As MMSE score declined over time, the percent of frail individuals increased in a linear fashion. Frailty and cognitive impairment are independent risk factors for mortality after controlling for all covariates (HR 2.03 95% CI 1.57–2.62; HR 1.26 95% CI 1.05–1.52, respectively). When both cognitive impairment and frailty were added to the model, HR for individuals with cognitive impairment was no longer statistically significant. The relation between frailty and cognitive impairment needs careful analysis in this population to establish pathways increasing mortality and decreasing quality of life. Our results suggest frailty is a stronger predictor of mortality for older Mexican Americans than cognitive impairment.
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影响因子：
4
作者：
Klein, BEK;Klein, R;Lee, KE
通讯作者：
Lee, KE
DOI：
10.1007/bf03404524
发表时间：
1999-09-01
影响因子：
4.3
作者：
Hogan, DB;Fung, TS;Ebly, EM
通讯作者：
Ebly, EM
DOI：
10.1111/j.1532-5415.2008.02136.x
发表时间：
2009-03-01
影响因子：
6.3
作者：
Avila-Funes, Jose Alberto;Amieva, Helene;Dartigues, Jean-Francois
通讯作者：
Dartigues, Jean-Francois
影响因子：
5.7
作者：
Auyeung, Tung Wai;Kwok, Timothy;Woo, Jean
通讯作者：
Woo, Jean
DOI：
10.1093/geronb/60.special_issue_2.s68
发表时间：
2005-10-01
影响因子：
6.2
作者：
Markides, KS;Eschbach, K
通讯作者：
Eschbach, K