Polyamine metabolism and cancer: treatments, challenges and opportunities.
Polyamine metabolism and cancer: treatments, challenges and opportunities.
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多胺代谢和癌症：治疗，挑战和机遇。
DOI：
10.1038/s41568-018-0050-3
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Pegg AE
中科院分区：
文献类型：
--
作者：
Casero RA Jr;Murray Stewart T;Pegg AE
我们对多胺的代谢和分子功能及其在癌症中的改变的理解的进展导致了对靶向多胺代谢作为抗癌策略的兴趣的复苏。对多胺代谢和其他癌症驱动途径（包括PTEN-PI 3 K-mTOR复合物1（mTORC 1），WNT信号传导和RAS途径）之间相互作用的认识不断增加，表明潜在的联合治疗将具有相当大的临床前景。此外，越来越多的有前途的临床试验与药物靶向多胺的治疗和预防正在进行中。新的见解分子机制连接失调的多胺catalysts和致癌建议额外的策略，可用于预防癌症的风险个体。此外，多胺阻断治疗，一种策略，结合多胺生物合成的抑制与多胺转运的同时封锁，可以是更有效的比基于多胺消耗单独的治疗，并可能涉及抗肿瘤免疫反应。这些发现开辟了新的途径，研究利用异常多胺代谢的抗癌治疗。
Advances in our understanding of the metabolism and molecular functions of polyamines and their alterations in cancer have led to resurgence in the interest of targeting polyamine metabolism as an anticancer strategy. Increasing knowledge of the interplay between polyamine metabolism and other cancer-driving pathways, including the PTEN–PI3K–mTOR complex 1 (mTORC1), WNT signalling and RAS pathways, suggests potential combination therapies that will have considerable clinical promise. Additionally , an expanding number of promising clinical trials with agents targeting polyamines for both therapy and prevention are ongoing. New insights into molecular mechanisms linking dysregulated polyamine catabolism and carcinogenesis suggest additional strategies that can be used for cancer prevention in at-risk individuals. In addition, polyamine blocking therapy, a strategy that combines the inhibition of polyamine biosynthesis with the simultaneous blockade of polyamine transport, can be more effective than therapies based on polyamine depletion alone and may involve an antitumour immune response. These findings open up new avenues of research into exploiting aberrant polyamine metabolism for anticancer therapy.
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影响因子：
--
作者：
Alexander ET;Minton A;Peters MC;Phanstiel O 4th;Gilmour SK
通讯作者：
Gilmour SK
影响因子：
3.5
作者：
Chaturvedi R;de Sablet T;Coburn LA;Gobert AP;Wilson KT
通讯作者：
Wilson KT
影响因子：
5.2
作者：
Asai Y;Itoi T;Sugimoto M;Sofuni A;Tsuchiya T;Tanaka R;Tonozuka R;Honjo M;Mukai S;Fujita M;Yamamoto K;Matsunami Y;Kurosawa T;Nagakawa Y;Kaneko M;Ota S;Kawachi S;Shimazu M;Soga T;Tomita M;Sunamura M
通讯作者：
Sunamura M
影响因子：
4.8
作者：
Basu, Indranil;Locker, Joseph;Schramm, Vern L.
通讯作者：
Schramm, Vern L.
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C