New DNA polymorphism: evidence for a low salt, left-handed form of poly(dG-m5dC).

New DNA polymorphism: evidence for a low salt, left-handed form of poly(dG-m5dC).
复制标题

新的 DNA 多态性:低盐左手形式聚 (dG-m5dC) 的证据。

DOI:
10.1093/nar/13.11.4133
复制
发表时间:
1985
影响因子:
14.9
通讯作者:
Shafer,RH
Shafer,RH
中科院分区:
生物学2区
文献类型:
--
作者:
Feuerstein,BG;Marton,LJ;Keniry,MA;Wade,DL;Shafer,RH

文献摘要

参考文献

被引文献

相似文献

本文研究了聚(dG-m5 dC)在不同盐浓度下的光谱性质。聚(dG-m5 dC)的低盐溶液([Na+])< 2 mM)在高盐([Na+] = 1.75 M)下产生典型的左手Z型圆二色性(CD)光谱。中等盐浓度的聚(dG-m5 dC)溶液,例如,低盐形式的聚(dG-m5 dC)的31 P NMR光谱显示两个分离良好的峰,分离1.4ppm,与二核苷酸重复一致。动力学研究表明,从低盐形式到右手B形式的转变是缓慢的,正如预期的主要构象变化。这些结果表明,聚(dG-m5 dC)中的Z构象可以在非常低的盐和高盐下稳定
Spectroscopic studies on solutions of poly(dG-m5dC) over a wide range of salt concentration are presented. Low salt solutions ([Na+]) < 2 mM) of poly(dG-m5dC) produce circular dichroism (CD) spectra typical of the left-handed, Z form at high salt ([Na+] = 1.75 M). Solutions of poly(dG-m5dC) at intermediate salt concentrations, e.g., 142 mM, yield CD spectra characteristic of the right-handed, B conformation.31P NMR spectra of the low salt form of poly(dG-m5dC) reveal two well separated peaks, split by 1.4 ppm, consistent with a dinucleotide repeat. Kinetic studies show that the transition from the low salt form to the right-handed B form is slow, as expected for a major conformational change. These results suggest that the Z conformation in poly(dG-m5dC) can be stabilized at very low salt as well as at high salt
社区老年人中体位性低血压的患病率较低。
DOI: 10.1001/jama.1987.03400110093033
发表时间: 1987
期刊: JAMA
影响因子: --
作者:
S. Mader;K. Josephson;L. Rubenstein
通讯作者: L. Rubenstein
自主神经功能障碍状态下心血管血流动力学的餐后改变。
DOI: --
发表时间: 1981
影响因子: 2.8
作者:
David Robertson;Dawn Wade;R. Robertson
通讯作者: R. Robertson
DOI: 10.1093/oxfordjournals.qjmed.a067221
发表时间: 1970
期刊: The Quarterly journal of medicine
影响因子: --
作者:
M. Gross
通讯作者: M. Gross
DOI: 10.1007/978-1-349-06859-3_9
发表时间: 1983
影响因子: 3.1
作者:
N. Simionescu;M. Simionescu
通讯作者: M. Simionescu
DOI: 10.1056/nejm198307143090205
发表时间: 1983
期刊: The New England journal of medicine
影响因子: --
作者:
Lipsitz,LA;NyquistJr,RP;Wei,JY;Rowe,JW
通讯作者: Rowe,JW