New DNA polymorphism: evidence for a low salt, left-handed form of poly(dG-m5dC).
New DNA polymorphism: evidence for a low salt, left-handed form of poly(dG-m5dC).
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新的 DNA 多态性:低盐左手形式聚 (dG-m5dC) 的证据。
DOI:
10.1093/nar/13.11.4133
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发表时间:
1985
影响因子:
14.9
通讯作者:
Shafer,RH
中科院分区:
文献类型:
--
作者:
Feuerstein,BG;Marton,LJ;Keniry,MA;Wade,DL;Shafer,RH
Spectroscopic studies on solutions of poly(dG-m5dC) over a wide range of salt concentration are presented. Low salt solutions ([Na+]) < 2 mM) of poly(dG-m5dC) produce circular dichroism (CD) spectra typical of the left-handed, Z form at high salt ([Na+] = 1.75 M). Solutions of poly(dG-m5dC) at intermediate salt concentrations, e.g., 142 mM, yield CD spectra characteristic of the right-handed, B conformation.31P NMR spectra of the low salt form of poly(dG-m5dC) reveal two well separated peaks, split by 1.4 ppm, consistent with a dinucleotide repeat. Kinetic studies show that the transition from the low salt form to the right-handed B form is slow, as expected for a major conformational change. These results suggest that the Z conformation in poly(dG-m5dC) can be stabilized at very low salt as well as at high salt
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DOI:
10.1001/jama.1987.03400110093033
发表时间:
1987
期刊:
JAMA
影响因子:
--
作者:
S. Mader;K. Josephson;L. Rubenstein
通讯作者:
L. Rubenstein
影响因子:
2.8
作者:
David Robertson;Dawn Wade;R. Robertson
通讯作者:
R. Robertson
DOI:
10.1093/oxfordjournals.qjmed.a067221
发表时间:
1970
期刊:
The Quarterly journal of medicine
影响因子:
--
作者:
M. Gross
通讯作者:
M. Gross
影响因子:
3.1
作者:
N. Simionescu;M. Simionescu
通讯作者:
M. Simionescu
DOI:
10.1056/nejm198307143090205
发表时间:
1983
期刊:
The New England journal of medicine
影响因子:
--
作者:
Lipsitz,LA;NyquistJr,RP;Wei,JY;Rowe,JW
通讯作者:
Rowe,JW