Associations of anger, vital exhaustion, anti-depressant use, and poor social ties with incident atrial fibrillation: The Atherosclerosis Risk in Communities Study.
Associations of anger, vital exhaustion, anti-depressant use, and poor social ties with incident atrial fibrillation: The Atherosclerosis Risk in Communities Study.
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DOI：
10.1177/2047487319897163
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发表时间：
2021-05-22
影响因子：
8.3
通讯作者：
Alonso A
中科院分区：
文献类型：
--
作者：
Garg PK;Claxton JS;Soliman EZ;Chen LY;Lewis TT;Mosley T;Alonso A
我们在一个中老年人的混血儿队列中研究了愤怒、生命衰竭、抗抑郁药物的使用和不良社会关系与AF事件的关系。该分析纳入了11445名社区动脉粥样硬化风险研究参与者，他们在1990 - 1992年基线时无房颤。生命衰竭在基线进行评估，并定义为21项生命衰竭问卷（VEQ）中最高四分位数的得分。基线抗抑郁药物使用情况是自我报告的。在基线上还使用了用于评估愤怒的Spielberger特质愤怒量表，以及用于评估社会关系的人际支持评估表和Lubben社会网络量表。通过心电图、房颤出院编码和死亡证明确定的主要结局是2016年的房颤事件。在23.4年的中位随访期间，共发现2220例房颤病例。在调整了年龄、种族中心、性别、教育程度和身高等因素后，第4 VEQ四分位数的参与者（参照=第1 VEQ四分位数）和报告使用抗抑郁药的参与者发生房颤的风险增加(风险比(HR)=1.45, 95%置信区间（CI） 1.29， VEQ为1.64；使用抗抑郁药物的HR=1.37, 95% CI 1.11, 1.69)。在对相关合并症进行额外调整后，第4个VEQ四分位数参与者观察到的房颤风险增加仍然显著（HR=1.20; CI 1.06, 1.35）。没有观察到愤怒或不良的社会关系与房颤的发展有显著的联系。生命衰竭与房颤发生风险增加有关。
We examined the relationships of anger, vital exhaustion, anti-depressant use, and poor social ties with incident AF in a biracial cohort of middle and older-aged adults. This analysis included 11,445 Atherosclerosis Risk in Communities Study participants who were free of AF at baseline in 1990–92. Vital exhaustion was assessed at baseline and defined as a score in the highest quartile on the 21-item Vital Exhaustion Questionnaire (VEQ). Baseline anti-depressant use was self-reported. The Spielberger Trait Anger Scale to assess anger and both the Interpersonal Support Evaluation List and the Lubben Social Network Scale to assess social ties were also administered at baseline. The primary outcome was incident AF through 2016, identified by electrocardiogram, hospital discharge coding of AF, and death certificates. A total of 2,220 incident AF cases were detected over a median follow-up of 23.4 years. After adjusting for age, race-center, sex, education, and height, participants in the 4th VEQ quartile (referent=1st VEQ quartile) and those reporting anti-depressant use were at increased risk for AF (hazard ratio (HR)=1.45, 95% confidence interval (CI) 1.29, 1.64 for VEQ; HR=1.37, 95% CI 1.11, 1.69 for anti-depressant use). The increased AF risk observed for 4th VEQ quartile participants remained significant after additional adjustment for relevant comorbidities (HR=1.20; CI 1.06, 1.35). No significant associations were observed for anger or poor social ties with development of AF. Vital exhaustion is associated with an increased risk of incident AF.
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影响因子：
37.8
作者：
Huxley RR;Lopez FL;Folsom AR;Agarwal SK;Loehr LR;Soliman EZ;Maclehose R;Konety S;Alonso A
通讯作者：
Alonso A
影响因子：
5.4
作者：
Garg PK;O'Neal WT;Chen LY;Loehr LR;Sotoodehnia N;Soliman EZ;Alonso A
通讯作者：
Alonso A
影响因子：
3.7
作者：
Knox, SS;Uvnäs-Moberg, K
通讯作者：
Uvnäs-Moberg, K
影响因子：
4.7
作者：
Nicolson, NA;van Diest, R
通讯作者：
van Diest, R
DOI：
10.1136/bmj.f288
发表时间：
2013-01-29
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Castro VM;Clements CC;Murphy SN;Gainer VS;Fava M;Weilburg JB;Erb JL;Churchill SE;Kohane IS;Iosifescu DV;Smoller JW;Perlis RH
通讯作者：
Perlis RH