Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use.
Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use.
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血液和脑脊液生物标志物对阿尔茨海默病的意义：敏感性，特异性和临床应用潜力。
DOI：
10.3390/jpm10030116
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发表时间：
2020-09-08
影响因子：
--
通讯作者：
Giliberto L
中科院分区：
文献类型：
--
作者：
d'Abramo C;D'Adamio L;Giliberto L
阿尔茨海默病（AD）是最常见的痴呆症类型，影响超过500万美国人，死亡率稳步上升，社会经济负担令人难以置信。不仅迄今为止的治疗努力未能达到显著的疗效，而且该病的真实的发病机制仍然不清楚。目前的理论是基于淀粉样蛋白斑块和tau神经元缠结的病理学发现，这些斑块和缠结积聚在受影响患者的脑实质中。这些发现与广泛的神经变性一起定义了疾病的诊断标准。首先检测脑脊液（CSF）中淀粉样蛋白和tau蛋白水平变化的能力，最近在血液中检测的能力，使我们能够使用这些生物标志物对人类AD进行特异性体内诊断。此外，AD的其他病理要素，如神经元丢失、炎症和代谢紊乱，已经转化为其他CSF和血液生物标志物的定义，这些生物标志物不是该疾病的特异性生物标志物，但是当与淀粉样蛋白和tau蛋白结合时，与从轻度认知障碍到AD痴呆的进展相关，或者识别将发展为AD病理的患者。在这篇综述中，我们讨论了阿尔茨海默病的当前和假设的生物标志物的作用，它们的特异性，以及当前高灵敏度平台对其外周检测的警告。
Alzheimer’s disease (AD) is the most common type of dementia, affecting more than 5 million Americans, with steadily increasing mortality and incredible socio-economic burden. Not only have therapeutic efforts so far failed to reach significant efficacy, but the real pathogenesis of the disease is still obscure. The current theories are based on pathological findings of amyloid plaques and tau neurofibrillary tangles that accumulate in the brain parenchyma of affected patients. These findings have defined, together with the extensive neurodegeneration, the diagnostic criteria of the disease. The ability to detect changes in the levels of amyloid and tau in cerebrospinal fluid (CSF) first, and more recently in blood, has allowed us to use these biomarkers for the specific in-vivo diagnosis of AD in humans. Furthermore, other pathological elements of AD, such as the loss of neurons, inflammation and metabolic derangement, have translated to the definition of other CSF and blood biomarkers, which are not specific of the disease but, when combined with amyloid and tau, correlate with the progression from mild cognitive impairment to AD dementia, or identify patients who will develop AD pathology. In this review, we discuss the role of current and hypothetical biomarkers of Alzheimer’s disease, their specificity, and the caveats of current high-sensitivity platforms for their peripheral detection.
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影响因子：
3.3
作者：
Bekris LM;Khrestian M;Dyne E;Shao Y;Pillai JA;Rao SM;Bemiller SM;Lamb B;Fernandez HH;Leverenz JB
通讯作者：
Leverenz JB
影响因子：
81.5
作者：
Blennow, Kaj;Brody, David L.;Zetterberg, Henrik
通讯作者：
Zetterberg, Henrik
影响因子：
4
作者：
Amadoro, Giuseppina;Corsetti, Veronica;Sancesario, Giuseppe
通讯作者：
Sancesario, Giuseppe
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Albert MS;DeKosky ST;Dickson D;Dubois B;Feldman HH;Fox NC;Gamst A;Holtzman DM;Jagust WJ;Petersen RC;Snyder PJ;Carrillo MC;Thies B;Phelps CH
通讯作者：
Phelps CH
影响因子：
14.5
作者：
Blennow, Kaj;Chen, Chun;Hoglund, Kina
通讯作者：
Hoglund, Kina