Comprehensive Review on Alzheimer's Disease: Causes and Treatment.
Comprehensive Review on Alzheimer's Disease: Causes and Treatment.
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DOI：
10.3390/molecules25245789
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发表时间：
2020-12-08
期刊：
影响因子：
--
通讯作者：
Karaman R
中科院分区：
文献类型：
--
作者：
Breijyeh Z;Karaman R
阿尔茨海默氏病（AD）是一种导致脑细胞变性的疾病，是痴呆症的主要原因，其特征是思维和个人日常活动独立性下降。AD被认为是一种多因素疾病：提出了两种主要假设作为AD的病因，胆碱能和淀粉样蛋白假设。此外，一些风险因素，如年龄增长，遗传因素，头部损伤，血管疾病，感染和环境因素在疾病中发挥作用。目前，仅有两类批准的治疗AD的药物，包括胆碱酯酶抑制剂和N-甲基d-天冬氨酸（NMDA）拮抗剂，其仅在治疗AD的症状方面有效，但不能治愈或预防该疾病。如今，该研究的重点是通过针对多种机制来了解AD病理学，例如异常tau蛋白代谢、β-淀粉样蛋白、炎症反应以及胆碱能和自由基损伤，旨在开发能够阻止或改变AD进程的成功治疗方法。这篇综述讨论了目前可用的药物和未来的理论开发新的治疗AD，如疾病修饰疗法（DMT），分子伴侣和天然化合物。
Alzheimer’s disease (AD) is a disorder that causes degeneration of the cells in the brain and it is the main cause of dementia, which is characterized by a decline in thinking and independence in personal daily activities. AD is considered a multifactorial disease: two main hypotheses were proposed as a cause for AD, cholinergic and amyloid hypotheses. Additionally, several risk factors such as increasing age, genetic factors, head injuries, vascular diseases, infections, and environmental factors play a role in the disease. Currently, there are only two classes of approved drugs to treat AD, including inhibitors to cholinesterase enzyme and antagonists to N-methyl d-aspartate (NMDA), which are effective only in treating the symptoms of AD, but do not cure or prevent the disease. Nowadays, the research is focusing on understanding AD pathology by targeting several mechanisms, such as abnormal tau protein metabolism, β-amyloid, inflammatory response, and cholinergic and free radical damage, aiming to develop successful treatments that are capable of stopping or modifying the course of AD. This review discusses currently available drugs and future theories for the development of new therapies for AD, such as disease-modifying therapeutics (DMT), chaperones, and natural compounds.
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影响因子：
5.6
作者：
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营养和年龄：专注于阿尔茨海默氏病。
影响因子：
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