Prognostic and immune-related value of STK17B in skin cutaneous melanoma.
Prognostic and immune-related value of STK17B in skin cutaneous melanoma.
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DOI：
10.1371/journal.pone.0263311
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Shi X;Zhou Q;Huang B;Xia S;Jiang Y;Fang S;Lin J
皮肤黑色素瘤（Skin cutaneous melanoma，SKCM）是一种常见的恶性肿瘤，其死亡率呈持续上升趋势。本研究对丝氨酸/苏氨酸激酶17 B（Serine/Threonine Kinase 17 B，STK 17 B）在SKCM中的临床意义进行了一系列分析，以期为SKCM的诊断和治疗提供新的生物标志物。RNA序列数据从癌症基因组图谱和基因型-组织表达数据库获得。将468例SKCM患者分为STK 17 B高表达组和低表达组，采用Bioconductor软件包进行差异表达基因分析。“clusterProfiler”的R包用于基因本体、基因和基因组的京都百科全书和基因集富集分析。利用STRING数据库和ssGSEA分别构建了蛋白质相互作用网络和免疫浸润景观。STK 17 B在SKCM中的表达低于正常组织。STK 17 B的表达与SKCM患者的T分期、Breslow深度、放射治疗、黑色素瘤Clark分级、病理分期等临床病理特征相关。Kaplan-Meier曲线分析显示STK 17 B低表达与总生存率和疾病特异性生存率相关。我们构建列线图来预测SKCM患者的1年、3年和5年生存率。功能富集分析显示STK 17 B相关差异表达基因在细胞分化和免疫相关过程中富集。STK 17 B表达水平与免疫细胞浸润水平呈正相关。在本研究中，我们发现STK 17 B在免疫浸润中起重要作用，可能成为SKCM患者诊断和预后的新生物标志物。
Skin cutaneous melanoma (SKCM) is a common cancer of which mortality is increasing continuously. Our study conducted a series of analyses on the clinical significance of Serine/threonine kinase 17B (STK17B) in SKCM to provide a new biomarker for diagnosis and treatment. The RNA-sequence data were obtained from The Cancer Genome Atlas and Genotype-Tissue Expression databases. The data of 468 SKCM patients were divided into STK17B high- and low-expression groups and analyzed by Bioconductor package to identify the differential expressed genes. The R package of “clusterProfiler” was used for Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene-Set Enrichment Analysis analyses. A protein-protein interaction network and immune infiltration landscape were respectively constructed via STRING database and ssGSEA. STK17B had lower expression in SKCM than normal tissues. Besides, STK17B expression was significantly related to some clinicopathological characteristics in SKCM patients including T stage, Breslow depth, radiation therapy, melanoma Clark level, and pathologic stage. The Kaplan-Meier curve analyses revealed that the low expression of STK17B was correlated with poor overall survival and disease-specific survival. We constructed nomograms to predict the 1-, 3-, and 5-year survival of SKCM patients. The function enrichment analyses showed STK17B-related differential expressed genes were enriched in cellular differentiation and immune-related progress. STK17B expression level were positively correlated with infiltrating level of immune cells. In this study, we found that STK17B, which played an important role in immune infiltration, could be a new biomarker for diagnosis and prognosis in SKCM patients.
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影响因子：
5.5
作者：
Cao Y;Xie J;Chen L;Hu Y;Zhai L;Yuan J;Suo L;Shen Y;Ye R;Li J;Gong Z;Dong Y;Bao W;Li H;Wang M
通讯作者：
Wang M
影响因子：
4.4
作者：
McGargill, Maureen A.;Choy, Carmen;Hedrick, Stephen M.
通讯作者：
Hedrick, Stephen M.
DOI：
10.1016/j.ijrobp.2013.08.035
发表时间：
2014-04-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Barker CA;Postow MA
通讯作者：
Postow MA
影响因子：
64.8
作者：
Twyman-Saint Victor, Christina;Rech, Andrew J.;Maity, Amit;Rengan, Ramesh;Pauken, Kristen E.;Stelekati, Erietta;Benci, Joseph L.;Xu, Bihui;Dada, Hannah;Odorizzi, Pamela M.;Herati, Ramin S.;Mansfield, Kathleen D.;Patsch, Dana;Amaravadi, Ravi K.;Schuchter, Lynn M.;Ishwaran, Hemant;Mick, Rosemarie;Pryma, Daniel A.;Xu, Xiaowei;Feldman, Michael D.;Gangadhar, Tara C.;Hahn, Stephen M.;Wherry, E. John;Vonderheide, Robert H.;Minn, Andy J.
通讯作者：
Minn, Andy J.
STK17B 通过 AKT/GSK-3β/Snail 信号传导促进肝细胞癌的癌变和转移。
影响因子：
9
作者：
Lan Y;Han J;Wang Y;Wang J;Yang G;Li K;Song R;Zheng T;Liang Y;Pan S;Liu X;Zhu M;Liu Y;Meng F;Mohsin M;Cui Y;Zhang B;Subash S;Liu L
通讯作者：
Liu L