Metagenomics and chemotherapy-induced nausea: A roadmap for future research.
Metagenomics and chemotherapy-induced nausea: A roadmap for future research.
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作者：
Crowder SL;Hoogland AI;Welniak TL;LaFranchise EA;Carpenter KM;Li D;Rotroff DM;Mariam A;Pierce CM;Fischer SM;Kinney AY;Dong-Binh Tran T;Rastegari F;Berry DL;Extermann M;Kim RD;Tometich DB;Figueiredo JC;Muzaffar J;Bari S;Turner K;Weinstock GM;Jim HSL
不受控制的化疗引起的恶心和呕吐（CINV）可降低患者的生活质量，并可能导致过早停止化疗。虽然恶心和呕吐通常被归为一类，但研究表明，止吐药对化疗引起的呕吐（CIV）临床有效，但对化疗引起的恶心（CIN）效果较差。恶心仍然是高达68%的患者的问题谁是处方指南一致的止吐药。尽管CIN的患病率很高，但关于其独立于CIV的病因学知之甚少。在这篇综述文章中，我们总结了一个宏基因组学的研究和治疗CIN的目标，鼓励未来的研究。宏基因组学关注遗传风险因素，包括人类（即，宿主）和肠道微生物遗传变异。迄今为止，很少有工作集中在宏基因组学作为CIN的假定生物学机制。宏基因组学有可能成为一个强大的工具，通过确定新的生物学途径和干预靶点，促进对CIN的科学理解。在人口统计学、临床和患者报告的风险因素的背景下对宏基因组学进行研究可能有助于识别有风险的患者，并促进CIN的预防和管理。在本文中，我们提出了一个全面的，宏基因组学的方法来调查遗传风险因素，包括人类（即，宿主）和肠道微生物遗传变异。在总结遗传和肠道微生物与化疗诱导的恶心和其他胃肠道毒性的相关性后，概述了目前关于化疗诱导的恶心和呕吐的知识，包括神经生物学、治疗和相关风险因素。
Uncontrolled chemotherapy-induced nausea and vomiting (CINV) can reduce patients’ quality of life and may result in premature discontinuation of chemotherapy. Although nausea and vomiting are commonly grouped together, research has shown that antiemetics are clinically effective against chemotherapy-induced vomiting (CIV) but less so against chemotherapy-induced nausea (CIN). Nausea remains a problem for up to 68% of patients who are prescribed guideline-consistent antiemetics. Despite the high prevalence of CIN, relatively little is known regarding its etiology independent of CIV. In this review paper, we summarize a metagenomics approach to the study and treatment of CIN with the goal of encouraging future research. Metagenomics focuses on genetic risk factors, encompassing both human (i.e., host) and gut microbial genetic variation. Little work to date has focused on metagenomics as a putative biological mechanism of CIN. Metagenomics has the potential to be a powerful tool in advancing scientific understanding of CIN by identifying new biological pathways and intervention targets. Investigation of metagenomics in the context of well-established demographic, clinical, and patient-reported risk factors may help to identify patients at risk and facilitate prevention and management of CIN. In this paper we propose a comprehensive, metagenomic approach to investigating genetic risk factors, encompassing both human (i.e., host) and gut microbial genetic variation. An overview of current knowledge about chemotherapy induced nausea and vomiting, including the neurobiology, treatment, and associated risk factors is described following a summary of genetic and gut microbial associations with chemotherapy induced nausea and other gastrointestinal toxicities.
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影响因子：
6.7
作者：
Babaoglu, MO;Bayar, B;Bozkurt, A
通讯作者：
Bozkurt, A
影响因子：
5.2
作者：
Batista VL;da Silva TF;de Jesus LCL;Coelho-Rocha ND;Barroso FAL;Tavares LM;Azevedo V;Mancha-Agresti P;Drumond MM
通讯作者：
Drumond MM
DOI：
10.3322/caac.21398
发表时间：
2017-07-08
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Bhatt AP;Redinbo MR;Bultman SJ
通讯作者：
Bultman SJ
影响因子：
45.3
作者：
Bloechl-Daum, Brigitte;Deuson, Robert R.;Herrstedt, Jorn
通讯作者：
Herrstedt, Jorn
影响因子：
6.2
作者：
Colagiuri, Ben;Roscoe, Joseph A.;Colman, Lauren K.
通讯作者：
Colman, Lauren K.