Liver test abnormalities in asymptomatic and mild COVID-19 patients and their association with viral shedding time.
Liver test abnormalities in asymptomatic and mild COVID-19 patients and their association with viral shedding time.
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DOI：
10.4254/wjh.v14.i11.1953
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发表时间：
2022-11-27
影响因子：
2.4
通讯作者：
Chen XQ
中科院分区：
文献类型：
--
作者：
Yu SY;Xie JR;Luo JJ;Lu HP;Xu L;Wang JJ;Chen XQ
无症状感染和轻微症状在感染Omicron变异体的患者中很常见，肝脏检查异常的数据很少见。评估肝功能检查结果异常的无症状和轻度冠状病毒病2019（COVID-19）患者的临床特征。这项回顾性研究包括661名实验室确诊的无症状和轻度COVID-19患者，他们于2022年4月5日至2022年4月29日在宁波的两家临时医院接受治疗。收集临床信息和病毒脱落时间，并进行单变量和多变量logistic回归模型进行统计分析。在661例患者中，83例（12.6%）有肝功能检查异常，6例（0.9%）有肝损伤。肝功能异常与肝病史相关（P < 0.001），与男性和肥胖相关（P < 0.05）。丙氨酸氨基转移酶升高与肥胖（P < 0.05）和肝病史（P < 0.001）可靠相关。天冬氨酸转氨酶（AST）升高与肝病史可靠相关（P < 0.001），与年龄超过30岁潜在相关（P < 0.05）。AST ≥ 2×正常值上限与较长的病毒排出时间有可靠的相关性，特别是在轻型病例中。肥胖和肝病史是肝功能检查异常的危险因素。男性和年龄较大是潜在的风险因素。应注意无症状和轻度COVID-19患者的肝脏检查，这对评估病毒脱落时间具有至关重要的临床意义。
Asymptomatic infections and mild symptoms are common in patients infected with the Omicron variant, and data on liver test abnormalities are rare. To evaluated the clinical characteristics of asymptomatic and mild coronavirus disease 2019 (COVID-19) patients with abnormal liver test results. This retrospective study included 661 laboratory-confirmed asymptomatic and mild COVID-19 patients who were treated in two makeshift hospitals in Ningbo from April 5, 2022 to April 29, 2022. Clinical information and viral shedding time were collected, and univariate and multivariate logistic regression models were performed in statistical analyses. Of the 661 patients, 83 (12.6%) had liver test abnormalities, and 6 (0.9%) had liver injuries. Abnormal liver tests revealed a reliable correlation with a history of liver disease (P < 0.001) and a potential correlation with male sex and obesity (P < 0.05). Elevated alanine aminotransferase was reliably associated with obesity (P < 0.05) and a history of liver disease (P < 0.001). Elevated aspartate transaminase (AST) was reliably correlated with a history of liver disease (P < 0.001), and potentially correlated with age over 30 years (P < 0.05). There was a reliable correlation between AST ≥ 2× the upper limit of normal and a longer viral shedding time, especially in mild cases. Obesity and a history of liver disease are risk factors for liver test abnormalities. Being male and an older age are potential risk factors. Attention should be given to liver tests in asymptomatic and mild COVID-19 patients, which has crucial clinical significance for evaluating the viral shedding time.
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DOI：
10.1111/liv.14854
发表时间：
2021-06
期刊：
Liver international : official journal of the International Association for the Study of the Liver
影响因子：
--
作者：
Herta T;Berg T
通讯作者：
Berg T
影响因子：
7.3
作者：
Jacobsen H;Klein SL
通讯作者：
Klein SL
DOI：
10.1111/liv.14730
发表时间：
2021-01
期刊：
Liver international : official journal of the International Association for the Study of the Liver
影响因子：
--
作者：
Nardo AD;Schneeweiss-Gleixner M;Bakail M;Dixon ED;Lax SF;Trauner M
通讯作者：
Trauner M
影响因子：
13.5
作者：
Bloom, Patricia P.;Meyerowitz, Eric A.;Chung, Raymond T.
通讯作者：
Chung, Raymond T.
影响因子：
6.6
作者：
Sarin, Shiv Kumar;Choudhury, Ashok;Omata, Masao
通讯作者：
Omata, Masao