Sex Differences in Immunity to Viral Infections.
Sex Differences in Immunity to Viral Infections.
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DOI：
10.3389/fimmu.2021.720952
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发表时间：
2021
影响因子：
7.3
通讯作者：
Klein SL
中科院分区：
文献类型：
--
作者：
Jacobsen H;Klein SL
持续的COVID-19大流行提高了人们对SARS-CoV-2感染后免疫力和结果的性别特异性差异的认识。强有力的证据表明，COVID-19疾病严重程度的男性偏好被假设是由针对SARS-CoV-2的性别差异免疫应答介导的。这一假设是基于其他病毒感染的数据，包括流感病毒、艾滋病毒、肝炎病毒和其他已证明对病毒感染具有性别特异性免疫力的病毒。虽然男性更容易受到大多数病毒感染，但女性具有免疫学特征，使其更容易受到不同的免疫相关疾病的影响。性染色体补体及其相关基因和性类固醇激素在介导病毒感染免疫的性别差异中起重要作用。
The ongoing COVID-19 pandemic has increased awareness about sex-specific differences in immunity and outcomes following SARS-CoV-2 infection. Strong evidence of a male bias in COVID-19 disease severity is hypothesized to be mediated by sex differential immune responses against SARS-CoV-2. This hypothesis is based on data from other viral infections, including influenza viruses, HIV, hepatitis viruses, and others that have demonstrated sex-specific immunity to viral infections. Although males are more susceptible to most viral infections, females possess immunological features that render them more vulnerable to distinct immune-related disease outcomes. Both sex chromosome complement and related genes as well as sex steroids play important roles in mediating the development of sex differences in immunity to viral infections.
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