Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study.
Pre-Clinical Investigation of Liquid Paclitaxel for Local Drug Delivery: A Pilot Study.
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液体紫杉醇用于局部给药的临床前研究：一项初步研究。
DOI：
10.3390/ph13120434
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发表时间：
2020-11-28
期刊：
影响因子：
--
通讯作者：
Yazdani SK
中科院分区：
文献类型：
--
作者：
Cawthon CV;Cooper K;Huett C;Lloret A;Villar-Matamoros E;Stokes L;Christians U;Schuler M;Yazdani SK
本初步研究的目的是探讨灌注导管将液体紫杉醇输送到动脉段的可行性。采用具有临床意义的兔髂-股损伤模型，测定1 h ~ 14天灌注导管局部灌注液体紫杉醇对血管壁的影响。研究了两种临床可用的液体紫杉醇治疗形式，一种是溶剂型（sb），一种是白蛋白结合型（nab），另一种是对照（无涂层气球）。药代动力学结果表明，与nab-紫杉醇相比，sb-紫杉醇在1 h时的保留率增加；然而，在第1天、第3天和第7天，没有观察到其他差异。14天的组织学结果显示，与nab-紫杉醇和未包被球囊处理的动脉相比，sb-紫杉醇处理的动脉内膜面积明显减少。此外，sb-紫杉醇组的狭窄百分比明显减少。这些结果支持紫杉醇局部液体输送到动脉段的概念。
The purpose of this pilot study was to investigate the feasibility of a perfusion catheter to deliver liquid paclitaxel into arterial segments. A clinically relevant rabbit ilio-femoral injury model was utilized to determine the impact of liquid paclitaxel delivered locally into the vessel wall using a perfusion catheter at 1 h to 14 days. Treatment by two clinically available forms of liquid paclitaxel, a solvent-based (sb) versus an albumin-bound (nab), along with a control (uncoated balloons), were investigated. Pharmacokinetic results demonstrated an increase in the retention of the sb-paclitaxel versus the nab-paclitaxel at 1 h; however, no other differences were observed at days one, three, and seven. Histological findings at 14 days showed significantly less neointimal area in the sb-paclitaxel treated arteries as compared with the nab-paclitaxel and the uncoated balloon-treated arteries. Additionally, percent area stenosis was significantly less in the sb-paclitaxel group. These results support the concept of local liquid delivery of paclitaxel into the arterial segments.
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影响因子：
4.6
作者：
Goel, Emily;Erwin, Megan;Yazdani, Saami K.
通讯作者：
Yazdani, Saami K.
影响因子：
2.4
作者：
MacTaggart, Jason N.;Phillips, Nicholas Y.;Kamenskiy, Alexey V.
通讯作者：
Kamenskiy, Alexey V.
影响因子：
37.8
作者：
Sousa, JE;Costa, MA;Serruys, PW
通讯作者：
Serruys, PW
影响因子：
11.3
作者：
Gongora, Carlos A.;Shibuya, Masahiko;Granada, Juan F.
通讯作者：
Granada, Juan F.
DOI：
10.1161/circinterventions.111.967794
发表时间：
2012-06-01
影响因子：
5.6
作者：
Speck, Ulrich;Cremers, Bodo;Scheller, Bruno
通讯作者：
Scheller, Bruno