Following gene duplication, paralog interference constrains transcriptional circuit evolution.
Following gene duplication, paralog interference constrains transcriptional circuit evolution.
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DOI：
10.1126/science.1240810
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发表时间：
2013-10-04
期刊：
影响因子：
--
通讯作者：
Johnson AD
中科院分区：
文献类型：
--
作者：
Baker CR;Hanson-Smith V;Johnson AD
大多数基因复制模型都假设复制前基因的祖先功能是独立的，因此可以在后代旁系同源物之间整齐地划分。然而，许多基因产物，例如转录调节因子，是协作装配中的组件。在这里，我们表明，此类蛋白质的复制和分歧的自然结果可能是旁系同源物之间的竞争性干扰。我们的示例基于必需的 MADS-box 转录调节因子 Mcm1 的复制，该调节因子存在于所有真菌中并调节大量基因。我们证明，一组历史氨基酸序列替换最大限度地减少了当代物种中旁系同源的干扰，并由此增加了该基因调控网络的分子复杂性。我们认为旁系同源干扰是基因重复进化的常见限制，并且需要解决它，这会产生额外的调控复杂性，以稳定基因组中的重复基因。
Most models of gene duplication assume that the ancestral functions of the preduplication gene are independent and can therefore be neatly partitioned between descendant paralogs. However, many gene products, such as transcriptional regulators, are components within cooperative assemblies; here, we show that a natural consequence of duplication and divergence of such proteins can be competitive interference between the paralogs. Our example is based on the duplication of the essential MADS-box transcriptional regulator Mcm1, which is found in all fungi and regulates a large set of genes. We show that a set of historical amino acid sequence substitutions minimized paralog interference in contemporary species and, in doing so, increased the molecular complexity of this gene regulatory network. We propose that paralog interference is a common constraint on gene duplicate evolution, and its resolution, which can generate additional regulatory complexity, is needed to stabilize duplicated genes in the genome.
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影响因子：
4.5
作者：
Bridgham, Jamie T.;Brown, Justine E.;Rodriguez-Mari, Adriana;Catchen, Julian M.;Thornton, Joseph W.
通讯作者：
Thornton, Joseph W.
DOI：
10.1007/bf00273599
发表时间：
1991-04-01
期刊：
MOLECULAR & GENERAL GENETICS
影响因子：
--
作者：
BOONCHIRD, C;MESSENGUY, F;DUBOIS, E
通讯作者：
DUBOIS, E
影响因子：
56.9
作者：
Lynch, M;Conery, JS
通讯作者：
Conery, JS
影响因子：
64.5
作者：
BENDER, A;SPRAGUE, GF
通讯作者：
SPRAGUE, GF
影响因子：
64.8
作者：
Finnigan, Gregory C.;Hanson-Smith, Victor;Stevens, Tom H.;Thornton, Joseph W.
通讯作者：
Thornton, Joseph W.