Effects of malathion metabolites on degranulation of and mediator release by human and rat basophilic cells.
Effects of malathion metabolites on degranulation of and mediator release by human and rat basophilic cells.
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马拉硫磷代谢物对人和大鼠嗜碱性细胞脱粒和介质释放的影响。
DOI：
10.1080/00984109708984019
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Rodgers,K
中科院分区：
文献类型：
--
作者：
Xiong,S;Rodgers,K
In the present study, the effects of malathion and malathion derivatives on histamine and β-hexosaminidase release by RBL-1 cells, rat peritoneal mast cells (RPMC), and human peripheral blood basophils (HPBB) and cutaneous mast calls were examined. One hour of incubation of RBL-1 cells with all organophosphate compounds tested, except for malathion and malathion monoacid, led to an increase in histamine release. β-Hexosamini dase, an enzyme released by basophilic cells and a biochemical marker of degranulation, was not released from RBL-1 cells after 1 h of exposure to organophosphate compounds. Within 4 h, all compounds tested increased the release of histamine and β-hexosamini dase. Longer exposures led to a decrease in the concentration of the compound that was required to cause mediator release. Exposure of RPMC to organophosphate compounds, with the exception of malathion monoacid and malathion (30 min) or malathion mono acid (1 h), led to the release of histamine, but not β-hexosaminidase. Incubation of HPBB with malaoxon (51.4 ± 2.8% total histamine released), malathion diacid (25.7 ± 2.9%), β-malathion monoacid (31.4 ± 2.8%), and isomalathion (57.1 ± 17.1%) for 1 h led to the release of histamine. Only malaoxon and isomalathion caused ^-hexosaminidase release from HPBB after a 1-h incubation. Incubation of cutaneous mast cells with mala oxon and fi-monoacid for 4 h led to increased release of histamine and β-hexosaminidase at levels comparable to compound 48/80. These data suggest that malathion metabolites can cause rapid release of histamine from basophilic cells from a variety of origins and species. With prolonged incubation, malathion itself caused the release of mast-cell media tors, suggesting that the cells may be capable of metabolizing malathion. These data also indicate a disparity between the release kinetics of two different mast-cell mediators con tained in granules by organophosphates, and that there are different mechanisms of medi ator release.
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大鼠骨髓来源的肥大细胞的功能和生化特征。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Broide,DH;Metcalfe,DD;Wasserman,SI
通讯作者：
Wasserman,SI
马拉硫磷的急性和亚急性给药对小鼠细胞和体液免疫反应缺乏免疫抑制作用
DOI：
--
发表时间：
1986
期刊：
影响因子：
--
作者：
K. Rodgers;N. Leung;C. Ware;B. Devens;T. Imamura
通讯作者：
T. Imamura
DOI：
10.1111/apm.1966.66.3.289
发表时间：
1966-01-01
期刊：
ACTA PATHOLOGICA ET MICROBIOLOGICA SCANDINAVICA
影响因子：
--
作者：
ENERBACK, L
通讯作者：
ENERBACK, L
硫代磷酸酯和相关酯作为工业有机磷杀虫剂中的杂质存在的毒理学特性。
DOI：
10.1080/15287398109529996
发表时间：
1981
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
Umetsu,N;Mallipudi,NM;Toia,RF;March,RB;Fukuto,TR
通讯作者：
Fukuto,TR
人嗜碱性粒细胞脱颗粒：二价青霉酰半抗原导致的组胺释放和脱敏的定量分析。
影响因子：
4.4
作者：
M. Dembo;B. Goldstein;A. Sobotka;L. Lichtenstein
通讯作者：
L. Lichtenstein