Modeling prenatal opioid exposure in animals: Current findings and future directions.

Modeling prenatal opioid exposure in animals: Current findings and future directions.
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DOI:
10.1016/j.yfrne.2017.09.001
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发表时间:
2018-10
影响因子:
7.4
通讯作者:
Vassoler FM
Vassoler FM
中科院分区:
医学1区
文献类型:
--
作者:
Byrnes EM;Vassoler FM

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The past decade has seen a drastic rise in the number of infants exposed to opioids in utero. It is unclear what lasting effect this exposure may have on these children. Animal models of prenatal opioid exposure may provide insight into potential areas of vulnerability. The present review summarizes the findings across animal models of prenatal opioid exposure, including exposure to morphine, methadone, buprenorphine, and oxycodone. Details regarding the drug, doses, and duration of treatment, as well as key findings, are summarized in tables with associated references. Finally, significant gaps in the current preclinical literature and future directions are discussed.
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