Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem.
Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem.
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DOI：
10.1111/j.1365-2958.2008.06363.x
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发表时间：
2008-09
影响因子：
3.6
通讯作者：
Skaar, Eric P.
中科院分区：
文献类型：
--
作者：
Reniere, Michelle L.;Skaar, Eric P.
铁的获取对大多数致病细菌来说是一个至关重要的过程，因为铁是感染期间的限制性营养物质。金黄色葡萄球菌是一种越来越重要的病原体，它通过阐述铁调节的表面决定系统(ISD)从宿主血红素中获取铁。ISDG和ISDI是血红素加氧酶，它们被认为是降解细菌细胞质中的外源血红素的一种机制，以释放游离铁用作营养源。在此，网络报道，IsdG和ISDI对于金黄色葡萄球菌的生长都是重要的，它们都是以氯化血红素为唯一铁源的，并且对于金黄色葡萄球菌的完全致病是必要的。对这些酶的调控研究表明，IsdG和ISDI受到铁和血红素通过转录和转录后机制的不同调控。此外，在脓肿形成部位的感染组织中发现ISDI的表达，这表明脓肿是宿主体内缺铁的微环境。这些发现表明，金黄色葡萄球菌不同地调节IsdG和ISDI，以响应感染期间铁和血红素可获得性的变化。
Iron acquisition is a vital process for most pathogenic bacteria, as iron is a limiting nutrient during infection. Staphylococcus aureus, an increasingly important pathogen, acquires iron from host heme via elaboration of the iron-regulated surface determinant system (Isd). IsdG and IsdI are heme oxygenases that have been proposed to degrade exogenous heme in the bacterial cytoplasm as a mechanism to liberate free iron for use as a nutrient source. Herein, web report that IsdG and IsdI are both important for S. aureus growth on hemin as a sole iron source and are necessary for full S. aureus pathogenesis. Investigations into the regulation of these enzymes revealed that IsdG and IsdI are differentially regulated by iron and heme through both transcriptional and post-transcriptional mechanisms. Additionally, IsdI was found to be expressed in infected tissues at the sites of abscess formation, suggesting that abscesses are iron-starved microenvironments inside the host. These findings suggest that S. aureus differentially regulates IsdG and IsdI in response to alterations in iron and heme availability during infection.
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DOI：
10.1099/00221287-6-1-2-95
发表时间：
1952-01-01
期刊：
JOURNAL OF GENERAL MICROBIOLOGY
影响因子：
--
作者：
DUTHIE, ES;LORENZ, LL
通讯作者：
LORENZ, LL
影响因子：
3.2
作者：
Ratliff, M;Zhu, WM;Stojiljkovic, I
通讯作者：
Stojiljkovic, I
影响因子：
3.2
作者：
Schmitt, MP
通讯作者：
Schmitt, MP
影响因子：
3.1
作者：
Bibb, Lori A.;Kunkle, Carey A.;Schmitt, Michael P.
通讯作者：
Schmitt, Michael P.
影响因子：
3.5
作者：
Chipperfield, JR;Ratledge, C
通讯作者：
Ratledge, C