A finite strain nonlinear human mitral valve model with fluid-structure interaction.

A finite strain nonlinear human mitral valve model with fluid-structure interaction.
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DOI:
10.1002/cnm.2691
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发表时间:
2014-12
影响因子:
2.1
通讯作者:
Luo X
Luo X
中科院分区:
工程技术3区
文献类型:
--
作者:
Gao H;Ma X;Qi N;Berry C;Griffith BE;Luo X

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使用混合有限元浸入边界法开发了生理压力负载下的计算人体二尖瓣 (MV) 模型,该模型将基于实验的本构定律纳入三维流体-结构相互作用框架中。根据最近对健康人二尖瓣叶的机械测试,使用横向各向同性材料本构模型来表征 MV 组织的机械行为。我们的结果显示,在流速以及关闭和打开配置方面,与体内磁共振图像的测量结果具有良好的一致性。发现前叶中的应力高于后叶中的应力,并且集中在环带三角形和小叶腹部周围。结果还表明,腱索在阀门打开时为流动提供辅助孔口方面发挥着重要作用。尽管在未来的工作中需要克服一些差异,但我们的模拟表明,所开发的计算模型有望模拟体内 MV 动力学并提供体内测量无法获得的重要信息。 © 2014 作者。 《国际生物医学工程数值方法杂志》由 John Wiley & Sons Ltd 出版。
A computational human mitral valve (MV) model under physiological pressure loading is developed using a hybrid finite element immersed boundary method, which incorporates experimentally-based constitutive laws in a three-dimensional fluid-structure interaction framework. A transversely isotropic material constitutive model is used to characterize the mechanical behaviour of the MV tissue based on recent mechanical tests of healthy human mitral leaflets. Our results show good agreement, in terms of the flow rate and the closing and opening configurations, with measurements from in vivo magnetic resonance images. The stresses in the anterior leaflet are found to be higher than those in the posterior leaflet and are concentrated around the annulus trigons and the belly of the leaflet. The results also show that the chordae play an important role in providing a secondary orifice for the flow when the valve opens. Although there are some discrepancies to be overcome in future work, our simulations show that the developed computational model is promising in mimicking the in vivo MV dynamics and providing important information that are not obtainable by in vivo measurements. © 2014 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.
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