Mitral valve dynamics in structural and fluid-structure interaction models.
Mitral valve dynamics in structural and fluid-structure interaction models.
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DOI：
10.1016/j.medengphy.2010.07.008
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发表时间：
2010-11
影响因子：
2.2
通讯作者：
Burriesci, G.
中科院分区：
文献类型：
--
作者：
Lau, K. D.;Diaz, V.;Scambler, P.;Burriesci, G.
心脏瓣膜的建模和仿真是一个具有挑战性的生物力学问题，其原因在于解剖结构的多变性、脉动的生理压力载荷和三维各向异性的材料特性。目前基于有限元方法的瓣膜模型可分为：能够模拟血液与瓣膜之间相互作用的模型(流固耦合或“湿”模型)和不能模拟血液与瓣膜相互作用的模型(结构模型或“干”模型)。在这里，一个解剖大小的二尖瓣模型被用来比较结构和流体-结构相互作用技术在两种不同的模拟场景中的差异：瓣膜关闭和心脏周期。利用流体-结构相互作用，分别在直管体积和U形室体积中对阀门进行建模，以分析两种几何形状在流体和结构动力学耦合方面的差异。结构模型和流固耦合模型的计算结果表明，各种模型在闭合模拟中的应力分布相似，但大小和闭合构型不同。在心动周期模拟中，由于施加的压力载荷不同，结构模型和流固耦合模型中的瓣膜动力学存在显着差异。流体-结构相互作用模型的流体域的比较表明，与管状几何形状相比，管状几何形状产生的流体速度较慢，而涡量增加。总之，结构心脏瓣膜模型适用于静态结构(开启或关闭的瓣膜)的模拟，但为了模拟完整的动态行为，流固耦合模型是必需的。
Modelling and simulation of heart valves is a challenging biomechanical problem due to anatomical variability, pulsatile physiological pressure loads and 3D anisotropic material behaviour. Current valvular models based on the finite element method can be divided into: those that do model the interaction between the blood and the valve (fluid–structure interaction or ‘wet’ models) and those that do not (structural models or ‘dry’ models). Here an anatomically sized model of the mitral valve has been used to compare the difference between structural and fluid–structure interaction techniques in two separately simulated scenarios: valve closure and a cardiac cycle. Using fluid–structure interaction, the valve has been modelled separately in a straight tubular volume and in a U-shaped ventricular volume, in order to analyse the difference in the coupled fluid and structural dynamics between the two geometries. The results of the structural and fluid–structure interaction models have shown that the stress distribution in the closure simulation is similar in all the models, but the magnitude and closed configuration differ. In the cardiac cycle simulation significant differences in the valvular dynamics were found between the structural and fluid–structure interaction models due to difference in applied pressure loads. Comparison of the fluid domains of the fluid–structure interaction models have shown that the ventricular geometry generates slower fluid velocity with increased vorticity compared to the tubular geometry. In conclusion, structural heart valve models are suitable for simulation of static configurations (opened or closed valves), but in order to simulate full dynamic behaviour fluid–structure interaction models are required.
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DOI：
10.1098/rstb.2007.2123
发表时间：
2007-08-29
影响因子：
6.3
作者：
Kunzelman, K. S.;Einstein, D. R.;Cochran, R. P.
通讯作者：
Cochran, R. P.
影响因子：
--
作者：
Burriesci, G.;Marincola, F. Cavallo;Zervides, C.
通讯作者：
Zervides, C.
DOI：
10.1016/s0022-5223(99)70008-5
发表时间：
1999-10-01
影响因子：
6
作者：
Sakai, T;Okita, Y;Miki, S
通讯作者：
Miki, S
影响因子：
--
作者：
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通讯作者：
Patterson, EA
影响因子：
4.6
作者：
Votta, Emiliano;Maisano, Francesco;Redaelli, Alberto
通讯作者：
Redaelli, Alberto