Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients.
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DOI：
10.1371/journal.pone.0017387
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发表时间：
2011-03-29
期刊：
影响因子：
3.7
通讯作者：
Cascorbi I
中科院分区：
文献类型：
--
作者：
Binder A;May D;Baron R;Maier C;Tölle TR;Treede RD;Berthele A;Faltraco F;Flor H;Gierthmühlen J;Haenisch S;Huge V;Magerl W;Maihöfner C;Richter H;Rolke R;Scherens A;Uçeyler N;Ufer M;Wasner G;Zhu J;Cascorbi I
瞬时受体电位通道是热刺激和机械刺激的重要介质，在神经病理性疼痛中起重要作用。瞬时受体电位通道基因中的遗传变异对神经性疼痛的贡献尚不清楚。我们研究了瞬时受体电位锚蛋白1，瞬时受体电位褪黑激素8和瞬时受体电位香草酸1单核苷酸多态性的频率及其对神经性疼痛患者体感异常的影响。在德国神经性疼痛研究网络（Deutscher Forscbungsverbund Neuropathischer Schmerz）中，使用标准化定量感觉测试对371名神经性疼痛患者进行表型表征。采用焦磷酸测序法确定神经性疼痛患者和253名德国健康志愿者的瞬时受体电位通道基因中总共11个单核苷酸多态性。根据感官表型，分析了组间和组内以及亚组间的定量感官测试参数和单核苷酸多态性的相关性。单核苷酸多态性频率在两个队列之间没有差异。然而，在神经性疼痛患者中，瞬时受体电位锚蛋白1710G>A（rs920829，E179K）与反常热感觉的存在相关（p = 0.03），瞬时受体电位香草素11911A>G（rs8065080，I585V）与冷痛觉减退相关（p = 0.0035）。 确定了两个主要亚组，其特征在于保留（1）和受损（2）的感觉功能。在亚组1中，瞬时受体电位香草酸11911 A>G导致显著较少的热痛觉过敏、针刺痛觉过敏和机械感觉减退（p = 0.006，p = 0.005和p<0.001），瞬时受体电位香草酸11103 C>G（rs222747，M315 I）导致显著较少的冷感觉减退（p = 0.002），但在亚组2中不存在相关性。 在本研究中，我们没有发现证据表明瞬时受体电位通道的遗传变异参与神经病理性疼痛的表达，但瞬时受体电位通道多态性显着促进神经病理性疼痛患者的体感异常。
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient receptor potential melastin 8 and transient receptor potential vanilloid 1 single nucleotide polymorphisms and their impact on somatosensory abnormalities in neuropathic pain patients. Within the German Research Network on Neuropathic Pain (Deutscher Forscbungsverbund Neuropathischer Schmerz) 371 neuropathic pain patients were phenotypically characterized using standardized quantitative sensory testing. Pyrosequencing was employed to determine a total of eleven single nucleotide polymorphisms in transient receptor potential channel genes of the neuropathic pain patients and a cohort of 253 German healthy volunteers. Associations of quantitative sensory testing parameters and single nucleotide polymorphisms between and within groups and subgroups, based on sensory phenotypes, were analyzed. Single nucleotide polymorphisms frequencies did not differ between both the cohorts. However, in neuropathic pain patients transient receptor potential ankyrin 1 710G>A (rs920829, E179K) was associated with the presence of paradoxical heat sensation (p = 0.03), and transient receptor potential vanilloid 1 1911A>G (rs8065080, I585V) with cold hypoalgesia (p = 0.0035). Two main subgroups characterized by preserved (1) and impaired (2) sensory function were identified. In subgroup 1 transient receptor potential vanilloid 1 1911A>G led to significantly less heat hyperalgesia, pinprick hyperalgesia and mechanical hypaesthesia (p = 0.006, p = 0.005 and p<0.001) and transient receptor potential vanilloid 1 1103C>G (rs222747, M315I) to cold hypaesthesia (p = 0.002), but there was absence of associations in subgroup 2. In this study we found no evidence that genetic variants of transient receptor potential channels are involved in the expression of neuropathic pain, but transient receptor potential channel polymorphisms contributed significantly to the somatosensory abnormalities of neuropathic pain patients.
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影响因子：
14.5
作者：
Hansen, C;Hopf, HC;Treede, RD
通讯作者：
Treede, RD
影响因子：
7.4
作者：
Baron, Ralf;Toelle, Thomas R.;Freynhagen, Rainer
通讯作者：
Freynhagen, Rainer
DOI：
10.1038/nrd2757
发表时间：
2009-01
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
通讯作者：
--
影响因子：
7.4
作者：
Kim, HS;Neubert, JK;Dionne, RA
通讯作者：
Dionne, RA
影响因子：
7.4
作者：
Geber, Christian;Magerl, Walter;Birklein, Frank
通讯作者：
Birklein, Frank