Reduction of myocardial infarct size in rabbits and inhibition of activation of rabbit and human neutrophils by lidocaine.
Reduction of myocardial infarct size in rabbits and inhibition of activation of rabbit and human neutrophils by lidocaine.
复制标题
利多卡因减少兔心肌梗塞面积并抑制兔和人中性粒细胞的活化。
DOI：
10.1016/s0002-8703(97)70226-6
复制
发表时间：
1997
影响因子：
4.8
通讯作者：
Murray,JJ
中科院分区：
文献类型：
--
作者：
Vitola,JV;Forman,MB;Holsinger,JP;Atkinson,JB;Murray,JJ
心肌再灌注与缺血区活化的中性粒细胞内流增加和细胞内钠蓄积有关。利多卡因是一种钠通道阻滞剂，也能抑制几种中性粒细胞的功能。我们研究了利多卡因对缺血30分钟和再灌注48小时的兔脑梗塞范围的影响。阻断期间，动物随机给予利多卡因(10 mg/kg，n=11)或生理盐水(n=11)。组织学测量坏死区(AN)，并表示为危险区(AR)的百分比。两组的心肌耗氧量和危险灌注床相似。与对照组相比，利多卡因可缩小脑梗塞面积(AN/AR分别为30%±4%和61%±5%；P=0.0001)。这种减少与中性粒细胞浸润和再灌流心肌中出血程度的显着减少有关。利多卡因还显著抑制兔和人全血中中性粒细胞产生超氧阴离子。因此，利多卡因治疗可显著缩小兔模型的心肌梗死范围，部分是通过减少中性粒细胞对存活细胞的损伤，这表明利多卡因可能有助于药物或机械再灌注患者的心肌挽救。(《美国心脏杂志》1997；133：315-22)
Myocardial reperfusion is associated with increased influx of activated neutrophils and intracellular accumulation of sodium in the ischemic zone. Lidocaine is a sodium channel blocker that also inhibits several neutrophil functions. We investigated the effect of lidocaine on infarct size in rabbits undergoing 30 minutes of ischemia and 48 hours of reperfusion. Animals randomly received lidocaine (10 mg/kg, n = 11) or saline ( n = 11) during occlusion. The area of necrosis (AN) was measured histologically and expressed as a percentage of the area at risk (AR). Myocardial oxygen consumption and the perfusion bed at risk were similar in the two groups. Lidocaine reduced infarct size compared with control (AN/AR = 30% ± 4% vs 61% ± 5%, respectively; p = 0.0001). This reduction was associated with a significant decrease in neutrophil infiltration and in the degree of hemorrhage in the reperfused myocardium. Lidocaine also significantly inhibited superoxide anion production by rabbit and human neutrophils in whole blood. Therefore, lidocaine treatment results in a significant reduction in infarct size in the rabbit model, partly through reduction of neutrophil-mediated injury to viable cells, suggesting that lidocaine may be useful to enhance myocardial salvage in patients undergoing pharmacologic or mechanical reperfusion. (Am Heart J 1997;133:315-22.)
登录
查看更多内容
长时间输注利多卡因后中性粒细胞超氧阴离子释放减少。
DOI：
--
发表时间：
1985
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Peck,SL;JohnstonJr,RB;Horwitz,LD
通讯作者：
Horwitz,LD
可卡因和心脏。
影响因子：
3.3
作者：
Tazelaar,HD;Karch,SB;Stephens,BG;Billingham,ME
通讯作者：
Billingham,ME
利多卡因对缺血性心肌损伤的潜在作用：实验和临床观察。
DOI：
10.1016/0022-4804(78)90044-6
发表时间：
1978
期刊：
The Journal of surgical research
影响因子：
--
作者：
H. Boudoulas;P. Karayannacos;R. Lewis;G. Kakos;J. Kilman;J. Vasko
通讯作者：
J. Vasko
在犬再灌注准备中使用冠状动脉内全氟化物减少梗塞面积。
影响因子：
37.8
作者：
M. Forman;S. Bingham;H. Kopelman;C. Wehr;M. Sandler;F. Kolodgie;W. Vaughn;G. Friesinger;R. Virmani
通讯作者：
R. Virmani
利多卡因抑制粒细胞粘附并防止粒细胞输送至炎症部位。
影响因子：
20.3
作者：
R. Macgregor;R. Thorner;D. M. Wright
通讯作者：
D. M. Wright