Cd271 mediates proliferation and differentiation of epidermal stem cells to support cutaneous burn wound healing
Cd271 mediates proliferation and differentiation of epidermal stem cells to support cutaneous burn wound healing
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Cd271介导表皮干细胞的增殖和分化以支持皮肤烧伤伤口愈合
DOI：
10.1007/s00441-017-2723-8
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发表时间：
2018-02
期刊：
影响因子：
--
通讯作者：
Yibing Wang
中科院分区：
文献类型：
--
作者：
Min Zhang;Yongqian Cao;Xiaohong Li;Lizhi Hu;Sahbi Khaled Taieb;Xiaolong Zhu;Jing Zhang;Yongqiang Feng;Ran Zhao;Mingqing Wang;Wenjun Xue;Zhanjie Yang;Yibing Wang
烧伤创面会大大降低患者的生理和心理方面的生活质量，甚至会威胁到他们的生命。已经提出了许多治疗方法，包括干细胞疗法，但到目前为止还没有有效的方法可以治愈这种损害。我们的研究强调了CD271在表皮干细胞(ESC)在烧伤创面愈合过程中的作用。CD271的表达随着烧伤创面的愈合而增加。在小鼠烧伤模型中，向创面注射过表达CD271的ESC可提高愈合率。CD271的过表达增强了ESC在体外的分化、增殖和迁移能力，甚至增强了其抗凋亡能力。这些结果与CD271通过提高皮肤干细胞的分化、增殖和迁移潜能而促进皮肤烧伤创面愈合的假说一致。我们的发现揭示了CD271在创面愈合中的作用，并可能为治疗皮肤烧伤创面提供新的治疗方法。
Burn wounds can significantly reduce the quality of life of patients with respect to their physiology and psychology and can even threaten their lives. Many treatments have been proposed, including stem cell therapy but no effective method can as yet cure such damage. Our study highlights the role of Cd271 in epidermal stem cells (eSC) during the healing of burn wounds. The expression of Cd271 increases together with burn wound healing. Injection of Cd271-over-expressing eSC into wounds promotes the healing rate in a mouse burn model. Over-expression of Cd271 enhances the abilities of eSC with regard to their differentiation, proliferation and migration and even their resistance to apoptosis in vitro. These results are in accordance with a hypothesis suggesting that Cd271 promotes the healing of skin burn wounds by improving the potential of eSC for differentiation, proliferation and migration. Our findings shed light on the role of Cd271 in wound healing and may provide new therapeutic approaches for curing burn wounds of the skin.
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影响因子：
3.6
作者：
Y. Iwata;Y. Hasebe;Seiji Hasegawa;S. Nakata;A. Yagami;K. Matsunaga;K. Sugiura;H. Akamatsu
通讯作者：
Y. Iwata;Y. Hasebe;Seiji Hasegawa;S. Nakata;A. Yagami;K. Matsunaga;K. Sugiura;H. Akamatsu
DOI：
10.1016/j.yccm.2011.12.002
发表时间：
2012
期刊：
Yearbook of Critical Care Medicine
影响因子：
--
作者：
B. Latenser
通讯作者：
B. Latenser
影响因子：
--
作者：
Murillo-Sauca O;Chung MK;Shin JH;Karamboulas C;Kwok S;Jung YH;Oakley R;Tysome JR;Farnebo LO;Kaplan MJ;Sirjani D;Divi V;Holsinger FC;Tomeh C;Nichols A;Le QT;Colevas AD;Kong CS;Uppaluri R;Lewis JS Jr;Ailles LE;Sunwoo JB
通讯作者：
Sunwoo JB
影响因子：
3.1
作者：
E. Kiwanuka;J. Junker;E. Eriksson
通讯作者：
E. Kiwanuka;J. Junker;E. Eriksson
DOI：
--
发表时间：
2003-12
影响因子：
--
作者：
Julin Xie;Tian-zeng Li;S. Qi;H. Bian;Jian-ding Cheng;Yingbin Xu;Hui-zhen Liang
通讯作者：
Julin Xie;Tian-zeng Li;S. Qi;H. Bian;Jian-ding Cheng;Yingbin Xu;Hui-zhen Liang