Surgical approaches to create murine models of human wound healing.
Surgical approaches to create murine models of human wound healing.
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DOI：
10.1155/2011/969618
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发表时间：
2011
影响因子：
--
通讯作者：
Gurtner GC
中科院分区：
文献类型：
--
作者：
Wong VW;Sorkin M;Glotzbach JP;Longaker MT;Gurtner GC
伤口修复是一个复杂的生物过程，在多种疾病状态下都会发生异常。虽然体外模型在确定特定细胞群体中的关键修复途径方面很重要，但体内模型对于更全面和更有针对性地了解人类伤口愈合是必要的。长期以来，实验室小鼠一直是最常见的动物研究工具，许多转基因品系和模型已经被开发出来，以帮助研究人员研究参与伤口修复和再生的分子途径。这篇文章旨在强调常见的皮肤病手术小鼠模型，并为研究人员提供更好的了解这些模型在翻译应用中的好处和局限性。
Wound repair is a complex biologic process which becomes abnormal in numerous disease states. Although in vitro models have been important in identifying critical repair pathways in specific cell populations, in vivo models are necessary to obtain a more comprehensive and pertinent understanding of human wound healing. The laboratory mouse has long been the most common animal research tool and numerous transgenic strains and models have been developed to help researchers study the molecular pathways involved in wound repair and regeneration. This paper aims to highlight common surgical mouse models of cutaneous disease and to provide investigators with a better understanding of the benefits and limitations of these models for translational applications.
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影响因子：
3.6
作者：
Hamou C;Callaghan MJ;Thangarajah H;Chang E;Chang EI;Grogan RH;Paterno J;Vial IN;Jazayeri L;Gurtner GC
通讯作者：
Gurtner GC
影响因子：
--
作者：
Carlson, Mark W;Alt-Holland, Addy;Egles, Christophe;Garlick, Jonathan A
通讯作者：
Garlick, Jonathan A
影响因子：
1.5
作者：
Akaishi, Satoshi;Akimoto, Masataka;Hyakusoku, Hiko
通讯作者：
Hyakusoku, Hiko
影响因子：
82.9
作者：
Ceradini, DJ;Kulkarni, AR;Gurtner, GC
通讯作者：
Gurtner, GC
影响因子：
3.6
作者：
El-Ftesi S;Chang EI;Longaker MT;Gurtner GC
通讯作者：
Gurtner GC