The roles of special proresolving mediators in pain relief
The roles of special proresolving mediators in pain relief
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特殊促缓解介质在缓解疼痛中的作用
DOI：
10.1515/revneuro-2017-0074
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发表时间：
2018-08
影响因子：
4.1
通讯作者：
Sun Tao
中科院分区：
文献类型：
--
作者：
Zhang Lan-yu;Jia Ming-rui;Sun Tao
急性炎症的消退，曾经被认为是一个被动的过程，现在被认为是一个主动的过程。内源性特殊促分辨介质（SPMs）的产生参与了这一过程。SPM，包括脂氧素、消退素、保护素和maresins，是在急性炎症消退期由ω-6花生四烯酸或ω-3多不饱和脂肪酸产生的内源性脂质介质。它们在各种炎症性疾病中具有有效的抗炎和促消退作用。由于有效的促消退和抗炎作用，SPM也用于缓解疼痛。本文综述了SPMs通过调节炎症介质、瞬时受体电位离子通道和中枢致敏作用于免疫细胞和神经细胞中各自的G蛋白偶联受体来使疼痛正常化的机制。SPM可以为预防和治疗与炎症相关的疼痛提供新的治疗方法。
Abstract The resolution of acute inflammation, once thought to be a passive process, is now recognized as an active one. The productions of endogenous special proresolving mediators (SPMs) are involved in this process. SPMs, including lipoxins, resolvins, protectins, and maresins, are endogenous lipid mediators generated from ω-6 arachidonic acid or ω-3 poly-unsaturated fatty acids during the resolution phase of acute inflammation. They have potent anti-inflammatory and proresolving actions in various inflammatory disorders. Due to the potent proresolving and anti-inflammatory effects, SPMs are also used for pain relief. This review focuses on the mechanisms by which SPMs act on their respective G-protein-coupled receptors in immune cells and nerve cells to normalize pain via regulating inflammatory mediators, transient receptor potential ion channels, and central sensitization. SPMs may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation.
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作者：
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