The genetic ancestry of African Americans, Latinos, and European Americans across the United States.-猫眼课题宝

DOI：

10.1016/j.ajhg.2014.11.010

发表时间：

2015-01-08

期刊：

American journal of human genetics

影响因子：

9.8

通讯作者：

中科院分区：

生物学1区

文献类型：

作者：

Bryc K;Durand EY;Macpherson JM;Reich D;Mountain JL

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289685/?report=classic

在过去的500年里，北美一直是印第安人、欧洲定居者和非洲人（主要是通过跨大西洋奴隶贸易带来的）不断混合的地方，塑造了后来成为美国的早期历史。我们研究了5269名自称非裔美国人、8663名拉丁裔美国人和148789名欧洲裔美国人的遗传祖先，他们都是23andMe的客户，结果表明，这些历史上相互作用的遗产在当今美国人的遗传祖先中是可见的。我们在所有研究群体中记录了普遍的混合祖先和不对称的男性和女性祖先贡献。我们表明，地区血统差异反映了历史事件，如早期西班牙殖民，来自欧洲许多地区的移民浪潮，以及美洲原住民在美国境内的被迫搬迁。这项研究揭示了美国内部和美国各地祖先的细微差异，并告知我们对种族和民族身份与遗传祖先之间关系的理解。

Over the past 500 years, North America has been the site of ongoing mixing of Native Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), shaping the early history of what became the United States. We studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and show that the legacy of these historical interactions is visible in the genetic ancestry of present-day Americans. We document pervasive mixed ancestry and asymmetrical male and female ancestry contributions in all groups studied. We show that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US. This study sheds light on the fine-scale differences in ancestry within and across the United States and informs our understanding of the relationship between racial and ethnic identities and genetic ancestry.