A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.
A molecular mucosal adjuvant to enhance immunity against pneumococcal infection in the elderly.
复制标题
DOI：
10.4110/in.2015.15.1.9
复制
发表时间：
2015-02
期刊：
影响因子：
6
通讯作者：
Fujihashi K
中科院分区：
文献类型：
--
作者：
Fukuyama Y;Ikeda Y;Ohori J;Sugita G;Aso K;Fujihashi K;Briles DE;McGhee JR;Fujihashi K
肺炎链球菌(肺炎球菌)引起一种主要的上呼吸道感染，通常会导致老年人的重病和死亡。因此，诱导对该病原体安全有效的黏膜免疫对于预防肺囊虫病的发生具有重要意义。然而，这是一个非常困难的任务，以诱导保护性黏膜免疫球蛋白A抗体反应在老年人。由编码Flt3配体cDNA(PFL)和CpG寡核苷酸(CpG ODN)的质粒组成的联合鼻佐剂成功地增强了老年小鼠对肺炎链球菌的黏膜免疫。特别是，以肺炎球菌表面蛋白A为基础的鼻用疫苗，加上PFL和CpG ODN，可以完全预防肺炎链球菌感染。这些结果表明，鼻腔给药的联合DNA佐剂提供了一个诱人的潜力，以保护老年人肺炎球菌。
Streptococcus pneumoniae (the pneumococcus) causes a major upper respiratory tract infection often leading to severe illness and death in the elderly. Thus, it is important to induce safe and effective mucosal immunity against this pathogen in order to prevent pnuemocaccal infection. However, this is a very difficult task to elicit protective mucosal IgA antibody responses in older individuals. A combind nasal adjuvant consisting of a plasmid encoding the Flt3 ligand cDNA (pFL) and CpG oligonucleotide (CpG ODN) successfully enhanced S. pneumoniae-specific mucosal immunity in aged mice. In particular, a pneumococcal surface protein A-based nasal vaccine given with pFL and CpG ODN induced complete protection from S. pneumoniae infection. These results show that nasal delivery of a combined DNA adjuvant offers an attractive potential for protection against the pneumococcus in the elderly.
登录
查看更多内容
DOI：
10.1084/jem.20011502
发表时间：
2002-01-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Campbell DJ;Butcher EC
通讯作者：
Butcher EC
DOI：
10.1073/pnas.0903181106
发表时间：
2009-05-12
影响因子：
11.1
作者：
Galli, Grazia;Hancock, Kathy;Stephenson, Iain
通讯作者：
Stephenson, Iain
影响因子：
5.5
作者：
Chung Truong Nguyen;Kim, Soo Young;Rhee, Joon Haeng
通讯作者：
Rhee, Joon Haeng
影响因子：
4.4
作者：
Campbell, JJ;Brightling, CE;Wardlaw, AJ
通讯作者：
Wardlaw, AJ
影响因子：
4.4
作者：
Hagiwara, Y;McGhee, JR;Fujihashi, K
通讯作者：
Fujihashi, K