Association of glycemic load with cardiovascular disease risk factors: the Women's Health Initiative Observational Study.
Association of glycemic load with cardiovascular disease risk factors: the Women's Health Initiative Observational Study.
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DOI：
10.1016/j.nut.2009.08.014
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Redden DT
中科院分区：
文献类型：
--
作者：
Shikany JM;Tinker LF;Neuhouser ML;Ma Y;Patterson RE;Phillips LS;Liu S;Redden DT
在妇女健康倡议观察性研究中，研究了膳食血糖负荷（GL）与心血管疾病（CVD）危险因素之间的关系，包括血浆脂蛋白/脂质水平、血压（BP）和葡萄糖代谢因素。随机抽取878名观察性研究参与者（50 - 79岁绝经后妇女）进行基线血液测量（白人647人，黑人104人，西班牙裔127人）。膳食GL是根据基线食物频率问卷来估计的，该问卷评估了前三个月的饮食摄入量。在基线访问时，参与者完成人口统计和健康习惯问卷，收集空腹血液样本，完成人体测量，并评估血压。在所有参与者中，GL与高密度脂蛋白（HDL）胆固醇呈负相关（P = 0.004），与log10转化的甘油三酯呈正相关（P = 0.008）。虽然种族/民族与GL和CVD危险因素之间没有统计学意义上的相互作用，但分层结果表明，GL与西班牙裔总胆固醇（P = 0.018）和低密度脂蛋白（LDL）胆固醇（P = 0.038）呈正相关。在白人中，随着GL的升高，HDL胆固醇有降低的趋势（P = 0.003），而GL与log10转化的甘油三酯呈正相关（P = 0.015）。血糖与高密度脂蛋白胆固醇、血糖与甘油三酯之间的关系也因BMI而异，尽管这种相互作用没有统计学意义。在这些总体健康的绝经后妇女中，GL与高密度脂蛋白胆固醇和甘油三酯有关。种族/民族和BMI对这些关联的暗示影响需要在更大规模的研究中得到证实。
Associations between dietary glycemic load (GL) and cardiovascular disease (CVD) risk factors, including plasma lipoprotein/lipid levels, blood pressure (BP), and glucose metabolism factors, in the Women's Health Initiative Observational Study were examined. A random sample of 878 Observational Study participants (postmenopausal women age 50 to 79 years) with baseline blood measures (647 White, 104 Black, 127 Hispanic) was included. Dietary GL was estimated from baseline food frequency questionnaires, which assessed dietary intake over the previous three months. At the baseline visit, participants completed demographic and health habit questionnaires, fasting blood samples were collected, anthropometric measurements were completed, and BP was assessed. In all participants combined, GL was inversely associated with high-density lipoprotein (HDL) cholesterol (P for trend = 0.004) and positively associated with log10-transformed triglycerides (P = 0.008). While there were no statistically significant interactions of race/ethnicity with associations between GL and CVD risk factors, stratified results were suggestive, showing that GL was positively associated with total cholesterol (P = 0.018) and low-density lipoprotein (LDL) cholesterol (P = 0.038) in Hispanics. In Whites, there was a trend of reduced HDL cholesterol with higher GL (P = 0.003), while GL was positively associated with log10-transformed triglycerides (P = 0.015). Associations between GL and HDL cholesterol and GL and triglycerides also varied by BMI, although the interactions were not statistically significant. Among these generally healthy postmenopausal women, GL was associated with HDL cholesterol and triglycerides. Suggestive effects of race/ethnicity and BMI on these associations need to be confirmed in larger studies.
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