Microglia in Aging and Alzheimer's Disease: A Comparative Species Review.
Microglia in Aging and Alzheimer's Disease: A Comparative Species Review.
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小胶质细胞在衰老和阿尔茨海默病：比较物种审查。
DOI：
10.3390/cells10051138
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发表时间：
2021-05-08
期刊：
影响因子：
6
通讯作者：
Richardson JR
中科院分区：
文献类型：
--
作者：
Edler MK;Mhatre-Winters I;Richardson JR
小胶质细胞是中枢神经系统的主要免疫细胞，有助于滋养和支持神经元，清除碎片，并对外来刺激做出反应。小胶质细胞受其环境的影响很大，在感染、创伤和神经变性状态下，其细胞形状、基因表达和功能行为发生快速变化。衰老还对小胶质细胞产生深远影响，导致慢性炎症和大脑对阿尔茨海默病中发生的神经退行性过程的易感性增加。尽管科学界在神经炎症领域的知识不断增长，但药物治疗年龄相关和神经退行性疾病的总体成功率仍然非常低。缺乏从动物模型到临床的转化的潜在原因包括使用单一物种模型，假设人类相似性，以及忽略来自其他物种的矛盾数据或信息。为了帮助选择验证和预测的动物模型和桥梁的翻译差距，这篇评论评估物种之间的相似性和差异，在小胶质细胞的激活和密度，形态和表型，细胞因子的表达，吞噬作用，和生产的氧化物种老化和阿尔茨海默氏病。
Microglia are the primary immune cells of the central nervous system that help nourish and support neurons, clear debris, and respond to foreign stimuli. Greatly impacted by their environment, microglia go through rapid changes in cell shape, gene expression, and functional behavior during states of infection, trauma, and neurodegeneration. Aging also has a profound effect on microglia, leading to chronic inflammation and an increase in the brain’s susceptibility to neurodegenerative processes that occur in Alzheimer’s disease. Despite the scientific community’s growing knowledge in the field of neuroinflammation, the overall success rate of drug treatment for age-related and neurodegenerative diseases remains incredibly low. Potential reasons for the lack of translation from animal models to the clinic include the use of a single species model, an assumption of similarity in humans, and ignoring contradictory data or information from other species. To aid in the selection of validated and predictive animal models and to bridge the translational gap, this review evaluates similarities and differences among species in microglial activation and density, morphology and phenotype, cytokine expression, phagocytosis, and production of oxidative species in aging and Alzheimer’s disease.
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DOI：
10.1002/alz.12318
发表时间：
2021-06
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Beckman D;Chakrabarty P;Ott S;Dao A;Zhou E;Janssen WG;Donis-Cox K;Muller S;Kordower JH;Morrison JH
通讯作者：
Morrison JH
DOI：
10.3402/pba.v2i0.18052
发表时间：
2012
期刊：
Pathobiology of aging & age related diseases
影响因子：
--
作者：
Asquith M;Haberthur K;Brown M;Engelmann F;Murphy A;Al-Mahdi Z;Messaoudi I
通讯作者：
Messaoudi I
影响因子：
16.2
作者：
Bhaskar, Kiran;Konerth, Megan;Kokiko-Cochran, Olga N.;Cardona, Astrid;Ransohoff, Richard M.;Lamb, Bruce T.
通讯作者：
Lamb, Bruce T.
影响因子：
3.9
作者：
Bickford PC;Flowers A;Grimmig B
通讯作者：
Grimmig B
影响因子：
4.2
作者：
Benzing, WC;Wujek, JR;Brunden, KR
通讯作者：
Brunden, KR