Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign.
Seroprevalence of SARS-CoV-2 immunoglobulin antibodies in Wuhan, China: part of the city-wide massive testing campaign.
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武汉市SARS-CoV-2免疫球蛋白抗体血清阳性率中国：全市大规模检测活动的一部分。
DOI：
10.1016/j.cmi.2020.09.044
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Pan Y;Li X;Yang G;Fan J;Tang Y;Hong X;Guo S;Li J;Yao D;Cheng Z;Yuan Y;Li Y;Wang X
2019年武汉爆发的新冠肺炎大流行中国，在遭受疾病重创和随后的城市封锁后，已经消退。有关武汉涉案人数的信息仍不充分。本研究旨在描述武汉市武昌区61,437名社区成员的筛查结果。2020年5月中旬，武汉市启动了全市范围内的SARS-CoV-2检测活动，旨在为武汉市民进行核酸和病毒抗体检测。这里展示了整群抽样武汉市武昌区61437名居民的筛查结果，中国。共有1470人(2.39%，95%可信区间2.27-2.52)检测到至少一种抗病毒抗体阳性。324例(0.53%，95%可信区间0.47~0.59)和1200例(1.95%，95%可信区间1.85~2.07)抗体阳性，54例(0.08%，95%可信区间0.07~0.12)两种抗体均阳性。女性抗体携带者阳性率高于男性携带者(男女比例为0.75)，尤其是老年人群(90岁以上年龄组为0.18)，提示血清抗体阳性率存在性别差异。用实时荧光定量聚合酶链式反应检测病毒核酸，发现8例(0.013%，95%可信区间0.006~0.026)无症状病毒携带者。武汉市SARS-CoV-2血清阳性率较低。大多数武汉居民仍然容易感染这种病毒。在获得有效的疫苗或抗病毒治疗之前，有必要采取预防措施，如戴口罩、经常保持手部卫生和适当的社交距离。
The outbreak of the 2019 coronavirus disease (COVID-19) pandemic in Wuhan, China, has subsided after being hard hit by the disease and subsequent city lockdown. Information on the number of people involved in Wuhan is still inadequate. This study aimed to describe the screening results of 61 437 community members in Wuchang District, Wuhan. In mid-May 2020, Wuhan launched a population-scale city-wide SARS-CoV-2 testing campaign, which aimed to perform nucleic acid and viral antibody testing for citizens in Wuhan. Here we show the screening results of cluster sampling of 61 437 residents in Wuchang District, Wuhan, China. A total of 1470 (2.39%, 95% CI 2.27–2.52) individuals were detected positive for at least one antiviral antibody. Among the positive individuals, 324 (0.53%, 95% CI 0.47–0.59) and 1200 (1.95%, 95% CI 1.85–2.07) were positive for immunoglobulin IgM and IgG, respectively, and 54 (0.08%, 95% CI 0.07–0.12) were positive for both antibodies. The positive rate of female carriers of antibodies was higher than those of male counterparts (male-to-female ratio of 0.75), especially in elderly citizens (ratio of 0.18 in 90+ age subgroup), indicating a sexual discrepancy in seroprevalence. In addition, viral nucleic acid detection using real-time PCR had showed 8 (0.013%, 95% CI 0.006–0.026) asymptomatic virus carriers. The seroprevalence of SARS-CoV-2 in Wuhan was low. Most Wuhan residents are still susceptible to this virus. Precautions, such as wearing mask, frequent hand hygiene and proper social distance, are necessary before an effective vaccine or antiviral treatments are available.
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作者：
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发表时间：
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期刊：
The Lancet. Microbe
影响因子：
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作者：
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