Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease.
Sugar or Fat? Renal Tubular Metabolism Reviewed in Health and Disease.
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糖还是肥的？《健康与疾病》中关于肾小管代谢的综述。
DOI：
10.3390/nu13051580
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发表时间：
2021-05-09
期刊：
影响因子：
5.9
通讯作者：
Gewin LS
中科院分区：
文献类型：
--
作者：
Gewin LS
肾脏是高度代谢活性的器官，其依赖于包括肾小管的特化上皮细胞来重吸收大部分过滤的水和溶质。这种重吸收大部分是由近端小管介导的，并且需要大量的能量来促进溶质运动。因此，近端小管使用脂肪酸氧化作为其优选的代谢途径，脂肪酸氧化产生比葡萄糖代谢更多的三磷酸腺苷（ATP）。肾损伤后，代谢改变，导致脂肪酸氧化减少和乳酸生成增加。这篇综述讨论了健康肾单位近端和远端肾小管段之间的代谢差异。此外，还讨论了急性肾损伤和慢性肾脏疾病的代谢变化，以及这些代谢变化如何影响肾小管修复和慢性肾脏疾病进展。
The kidney is a highly metabolically active organ that relies on specialized epithelial cells comprising the renal tubules to reabsorb most of the filtered water and solutes. Most of this reabsorption is mediated by the proximal tubules, and high amounts of energy are needed to facilitate solute movement. Thus, proximal tubules use fatty acid oxidation, which generates more adenosine triphosphate (ATP) than glucose metabolism, as its preferred metabolic pathway. After kidney injury, metabolism is altered, leading to decreased fatty acid oxidation and increased lactic acid generation. This review discusses how metabolism differs between the proximal and more distal tubular segments of the healthy nephron. In addition, metabolic changes in acute kidney injury and chronic kidney disease are discussed, as well as how these changes in metabolism may impact tubule repair and chronic kidney disease progression.
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影响因子：
--
作者：
BURCH, HB;NARINS, RG;LOWRY, OH
通讯作者：
LOWRY, OH
DOI：
10.1016/0005-2736(74)90286-7
发表时间：
1974-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
ARONSON, PS;SACKTOR, B
通讯作者：
SACKTOR, B
DOI：
10.1016/j.bbalip.2016.03.020
发表时间：
2016-10-01
影响因子：
4.8
作者：
Fukushima, Arata;Lopaschuk, Gary D.
通讯作者：
Lopaschuk, Gary D.
影响因子：
--
作者：
BURCH, HB;LOWRY, OH;FAGIOLI, S
通讯作者：
FAGIOLI, S
影响因子：
15.9
作者：
CERSOSIMO, E;JUDD, RL;MILES, JM
通讯作者：
MILES, JM