Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease.
Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease.
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DOI：
10.1016/j.jalz.2011.05.2416
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Lyketsos CG
中科院分区：
文献类型：
--
作者：
Mielke MM;Okonkwo OC;Oishi K;Mori S;Tighe S;Miller MI;Ceritoglu C;Brown T;Albert M;Lyketsos CG
穹窿是海马体的主要流出道，海马体是已知在阿尔茨海默病 (AD) 病程早期受到影响的大脑区域。本研究的目的是：1) 检查穹窿 DTI 测量值（分数各向异性 (FA) 和平均 (MD)、轴向 (DA) 和径向 (DR) 扩散率）、海马体积和记忆表现之间的横断面关系，2) 将穹窿 DTI 测量值与海马体积作为从遗忘性轻度认知障碍 (MCI) 进展和转变为 AD 痴呆的预测因子进行比较。 23 名 MCI 参与者接受了基线海马体积测定和弥散张量成像，并在基线、3、6、12 个月和 2.5 年接受了详细评估。六名参与者在后续行动中转变为 AD。使用手动测量确定穹窿和后扣带回 DTI 测量值以及海马体积。随机效应模型评估了每项神经影像学指标，作为 MMSE、CDR 框总和和记忆 z 分数下降的预测因子； ROC 分析检查了转化为 AD 的预测价值。穹窿 FA 与海马体积之间存在显着相关性。然而，只有穹窿测量值（FA、MD、DR、DA）与记忆 z 分数具有横截面相关性。穹窿 FA 和海马体积均可预测记忆力下降。单独而言，穹窿 FA 和 MD 以及海马体积是进展的非常好的预测因子，似然比 >83，准确度高于 90%。 Fornix FA 与记忆衰退和 AD 进展具有横向相关性和纵向预测性。手动绘制的穹窿 ROI 显示出与海马体积相当的前景，可以作为进展的预测生物标志物，并且值得在更大规模的研究中进行复制。
The fornix is the predominant outflow tract of the hippocampus, a brain region known to be affected early in the course of Alzheimer’s disease (AD). The aims of the present study were to: 1) examine the cross-sectional relationship between fornix DTI measurements (fractional anisotropy (FA), and mean (MD), axial (DA) and radial (DR) diffusivities), hippocampal volume, and memory performance, and 2) compare fornix DTI measures to hippocampal volumes as predictors of progression and transition from amnestic mild cognitive impairment (MCI) to AD dementia. 23 MCI participants with baseline hippocampal volumetry and diffusion tensor imaging received detailed evaluations at baseline, 3, 6, 12 months, and 2.5 years. Six participants converted to AD over the follow-up. Fornix and posterior cingulum DTI measurements and hippocampal volumes were ascertained using manual measures. Random effects models assessed each of the neuroimaging measures as predictors of decline on the MMSE, CDR-Sum of boxes and Memory z-scores; ROC analyses examined the predictive value for conversion to AD. There was a significant correlation between fornix FA and hippocampal volumes. However, only the fornix measurements (FA, MD, DR, DA) were cross-sectionally correlated with memory z-scores. Both fornix FA and hippocampal volumes were predictive of memory decline. Individually, fornix FA and MD and hippocampal volumes were very good predictors of progression with likelihood ratios>83, and better than 90% accuracy. Fornix FA both cross-sectionally correlated with and longitudinally predicted memory decline and progression to AD. Manually-drawn fornix ROI shows comparable promise to hippocampal volume as a predictive biomarker of progression and warrants replication in a larger study.
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