The gut microbiome: a new frontier in autism research.

The gut microbiome: a new frontier in autism research.
复制标题

DOI:
10.1007/s11920-012-0337-0
复制
发表时间:
2013-02
影响因子:
6.7
通讯作者:
Cubells, Joseph F.
Cubells, Joseph F.
中科院分区:
医学2区
文献类型:
--
作者:
Mulle, Jennifer G.;Sharp, William G.;Cubells, Joseph F.

文献摘要

参考文献

被引文献

相似文献

人类肠道中有一个复杂的微生物群落,它们深刻地影响着生长和发育的许多方面,包括神经系统的发育。高通量DNA测序方法的进步导致对这种肠道微生物组的知识迅速扩大。在这里,我们回顾了关于人类肠道微生物组的基本新数据,重点关注微生物组与自闭症谱系障碍(ASD)之间的潜在相互作用,并考虑了ASD中非典型喂养和营养模式以及它们如何与微生物组相互作用的研究。最后,我们选择性地调查了啮齿动物中微生物组对神经行为发育影响的研究结果。本文综述的证据表明,对肠道微生物组的深入了解可能为自闭症谱系障碍的研究开辟新的途径,包括潜在的新治疗策略。
The human gut harbors a complex community of microbes that profoundly influence many aspects of growth and development, including development of the nervous system. Advances in high-throughput DNA sequencing methods have led to rapidly expanding knowledge about this gut microbiome. Here, we review fundamental emerging data on the human gut microbiome, with a focus on potential interactions between the microbiome and autism spectrum disorders (ASD) and consider research on atypical patterns of feeding and nutrition in ASD and how they might interact with the microbiome. Finally we selectively survey results from studies in rodents on the impact of the microbiome on neurobehavioral development. The evidence reviewed here suggests that a deeper understanding of the gut microbiome could open up new avenues of research on ASD, including potential novel treatment strategies.
DOI: 10.1016/j.jpeds.2010.02.013
发表时间: 2010-08
影响因子: 5.1
作者:
Bandini, Linda G.;Anderson, Sarah E.;Curtin, Carol;Cermak, Sharon;Evans, E. Whitney;Scampini, Renee;Maslin, Melissa;Must, Aviva
通讯作者: Must, Aviva
DOI: 10.1177/089033402237909
发表时间: 2002-11-01
期刊: Journal of human lactation : official journal of International Lactation Consultant Association
影响因子: --
作者:
Bier, Jo-Ann Blaymore;Oliver, Tanya;Vohr, Betty R
通讯作者: Vohr, Betty R
DOI: 10.1038/nature09944
发表时间: 2011-05-12
期刊: NATURE
影响因子: 64.8
作者:
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者: Bork, Peer
DOI: 10.1073/pnas.1002601107
发表时间: 2010-06-29
影响因子: 11.1
作者:
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者: Knight, Rob
DOI: 10.1542/peds.101.1.e9
发表时间: 1998-01-01
期刊: PEDIATRICS
影响因子: 8
作者:
Horwood, LJ;Fergusson, DM
通讯作者: Fergusson, DM