Donor-derived acute myeloid leukemia in solid organ transplantation.
Donor-derived acute myeloid leukemia in solid organ transplantation.
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DOI：
10.1111/ajt.17174
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发表时间：
2022-12
期刊：
影响因子：
--
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中科院分区：
文献类型：
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我们报告急性髓性白血病（AML）的传播未被发现的捐赠从已故器官捐赠者的两个肾脏和一个肝脏受体。我们回顾了病历，并进行了分子分析和全外显子组测序（WES），以确定AML供体来源及其分子进化。肝脏受体在移植后11个月被诊断出，两个月后死于并发症。两个肾受体（R1和R2）在移植后19个月和20个月被诊断为白血病，并接受了治疗。R1在诊断后11个月死于并发症，而R2在复发前完全缓解了44个月。R2在10个月后死于同种异体骨髓移植的并发症。微卫星分析表明，供体嵌合体循环细胞从两个肾受体。有针对性的分子分析和医疗记录显示，供体和受体中存在NPM1突变，而FLT3仅在R1中发生突变。这些发现得到了WES的证实，WES揭示了R2中额外的创始者和克隆突变以及HLA基因组丢失。总之，我们报告了实体器官移植后AML传播的第一次深入基因组分析，揭示了不同的克隆进化，并为肿瘤逃逸提供了潜在的分子解释。
We report the transmission of acute myeloid leukemia (AML) undetected at donation from a deceased organ donor to two kidney and one liver recipients. We reviewed the medical records, and performed molecular analyses and whole exome sequencing (WES) to ascertain AML donor origin and its molecular evolution. The liver recipient was diagnosed eleven months after transplantation and died from complications two months later. The two kidney recipients (R1 and R2) were diagnosed nineteen and twenty months after transplantation and both received treatment for leukemia. R1 died of complications eleven months after diagnosis, while R2 went into complete remission for forty-four months, before relapsing. R2 died ten months later of complications from allogenic bone marrow transplantation. Microsatellite analysis demonstrated donor chimerism in circulating cells from both kidney recipients. Targeted molecular analyses and medical records revealed NPM1 mutation presence in the donor and recipients, while FLT3 was mutated only in R1. These findings were confirmed by WES, which revealed additional founder and clonal mutations, and HLA genomic loss in R2. In conclusion, we report the first in-depth genomic analysis of AML transmission following solid organ transplantation, revealing distinct clonal evolution, and providing a potential molecular explanation for tumor escape.
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在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
6.5
作者：
Dietz, Andrew C.;DeFor, Todd E.;Wagner, John E., Jr.
通讯作者：
Wagner, John E., Jr.
DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
影响因子：
6.2
作者：
Kauffman, HM;McBride, MA;Roza, AM
通讯作者：
Roza, AM
影响因子：
12.3
作者：
McLaren W;Gil L;Hunt SE;Riat HS;Ritchie GR;Thormann A;Flicek P;Cunningham F
通讯作者：
Cunningham F