Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men.
Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men.
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DOI：
10.2337/dc08-1377
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发表时间：
2009-02
期刊：
影响因子：
16.2
通讯作者：
Blair SN
中科院分区：
文献类型：
--
作者：
Lee DC;Sui X;Church TS;Lee IM;Blair SN
本研究的目的是检查心肺适能（以下简称适能）和各种肥胖指标与空腹血糖受损（IFG）和2型糖尿病风险的关系。研究设计和方法：这是一项前瞻性队列研究，共有14，006名男性（IFG分析7，795名），他们没有异常心电图或心脏病发作、中风、癌症或糖尿病史。在这些男性中，分别有3，612人（39，610人年）和477人（101，419人年）患IFG和2型糖尿病。多变量分析中，与最不符合20%相比，最符合20%的IFG和2型糖尿病风险分别低14%和52%（均P < 0.001）。BMI ≥30.0 kg/m2、腰围>102.0 cm或体脂百分比≥25的男性患2型糖尿病的风险分别是非肥胖男性的2.7倍、1.9倍和1.3倍（均P < 0.01），IFG的结果相似。在综合分析中，肥胖不健康（最不健康20%）的男性患2型糖尿病的风险是正常体重健康（最健康80%）男性的5.7倍。我们观察到BMI和健身与IFG以及腰围或体脂百分比和健身与IFG和2型糖尿病的联合关联具有相似的趋势。结论：低体能和肥胖增加IFG和2型糖尿病的风险，幅度大致相同。当同时考虑时，健身减弱但不能消除与肥胖相关的IFG和2型糖尿病的风险增加，并且在肥胖和不健康的男性中发现风险最高。
OBJECTIVE—The purpose of this study was to examine the associations of cardiorespiratory fitness (hereafter fitness) and various obesity measures with risks of incident impaired fasting glucose (IFG) and type 2 diabetes. RESEARCH DESIGN AND METHODS—This was a prospective cohort study of 14,006 men (7,795 for the analyses of IFG), who did not have an abnormal electrocardiogram or a history of heart attack, stroke, cancer, or diabetes. RESULTS—Of the men, 3,612 (39,610 person-years) and 477 (101,419 person-years) developed IFG and type 2 diabetes, respectively. Compared with the least fit 20% in multivariate analyses, IFG and type 2 diabetes risks in the most fit 20% were 14 and 52% lower, respectively (both P < 0.001). Men with BMI ≥30.0 kg/m2, waist girth >102.0 cm, or percent body fat ≥25 had 2.7-, 1.9-, and 1.3-fold higher risks for type 2 diabetes, respectively, compared with those for nonobese men (all P < 0.01), and the results for IFG were similar. In the combined analyses, obese unfit (least fit 20%) men had a 5.7-fold higher risk for type 2 diabetes compared with normal-weight fit (most fit 80%) men. We observed similar trends for the joint associations of BMI and fitness with IFG and those of waist girth or percent body fat and fitness with both IFG and type 2 diabetes. CONCLUSIONS—Low fitness and obesity increased the risks of IFG and type 2 diabetes by approximately similar magnitudes. When considered simultaneously, fitness attenuated but did not eliminate the increased risks of IFG and type 2 diabetes associated with obesity, and the highest risk was found in obese and unfit men.
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影响因子：
120.7
作者：
Sui, Xuemei;LaMonte, Michael J.;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
16.2
作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
3.4
作者：
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通讯作者：
Tuomilehto, Jaakko
影响因子：
120.7
作者：
Carnethon, MR;Gidding, SS;Liu, K
通讯作者：
Liu, K