Association of Maternal Metabolites and Metabolite Networks with Newborn Outcomes in a Multi-Ancestry Cohort.
Association of Maternal Metabolites and Metabolite Networks with Newborn Outcomes in a Multi-Ancestry Cohort.
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DOI：
10.3390/metabo13040505
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发表时间：
2023-03-31
期刊：
影响因子：
4.1
通讯作者：
Lowe WL Jr
中科院分区：
文献类型：
--
作者：
Gleason B;Kuang A;Bain JR;Muehlbauer MJ;Ilkayeva OR;Scholtens DM;Lowe WL Jr
子宫内环境对出生时的新生儿大小很重要，这与儿童肥胖有关。我们在一个2337对母亲-新生儿的多民族和多血统队列中研究了母亲代谢物水平与新生儿出生体重、皮褶总和（SSF）和脐带C肽之间的关系。对参与高血压和不良妊娠结局（HAPO）研究的女性在妊娠24-32周进行口服葡萄糖耐量试验期间采集的空腹和1 h母体血清样本进行靶向和非靶向代谢组学分析。在新生儿出生时进行人体测量。校正母体BMI和血糖后，代谢物分析显示母体代谢物水平与出生体重、SSF和脐带C肽之间存在显著相关性。在空腹状态下，甘油三酯与出生体重和SSF呈正相关，而几种长链酰基肉毒碱与出生体重和SSF呈负相关。在1小时，额外的代谢产物，包括支链氨基酸，脯氨酸和丙氨酸与新生儿的结局呈正相关。网络分析表明，相互连接的代谢物显着相关的新生儿表型的不同集群。总之，妊娠期间许多母体代谢物与新生儿出生体重、SSF和脐带C肽显著相关，而与母体BMI和葡萄糖无关，这表明除葡萄糖外的代谢物还影响新生儿出生时的大小和肥胖。
The in utero environment is important for newborn size at birth, which is associated with childhood adiposity. We examined associations between maternal metabolite levels and newborn birthweight, sum of skinfolds (SSF), and cord C-peptide in a multinational and multi-ancestry cohort of 2337 mother–newborn dyads. Targeted and untargeted metabolomic assays were performed on fasting and 1 h maternal serum samples collected during an oral glucose tolerance test performed at 24–32 week gestation in women participating in the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Anthropometric measurements were obtained on newborns at birth. Following adjustment for maternal BMI and glucose, per-metabolite analyses demonstrated significant associations between maternal metabolite levels and birthweight, SSF, and cord C-peptide. In the fasting state, triglycerides were positively associated and several long-chain acylcarnitines were inversely associated with birthweight and SSF. At 1 h, additional metabolites including branched-chain amino acids, proline, and alanine were positively associated with newborn outcomes. Network analyses demonstrated distinct clusters of inter-connected metabolites significantly associated with newborn phenotypes. In conclusion, numerous maternal metabolites during pregnancy are significantly associated with newborn birthweight, SSF, and cord C-peptide independent of maternal BMI and glucose, suggesting that metabolites in addition to glucose contribute to newborn size at birth and adiposity.
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影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
8.2
作者：
Kadakia, Rachel;Nodzenski, Michael;Lowe, William L., Jr.
通讯作者：
Lowe, William L., Jr.
影响因子：
2.2
作者：
Lee, Ji-Eun
通讯作者：
Lee, Ji-Eun
DOI：
10.1900/rds.2016.13.66
发表时间：
2016-01-01
期刊：
The review of diabetic studies : RDS
影响因子：
--
作者：
Liu, Zhenping;Jeppesen, Per B;Hermansen, Kjeld
通讯作者：
Hermansen, Kjeld
影响因子：
4.6
作者：
Chia, Ai-Ru;de Seymour, Jamie, V;Baker, Philip N.
通讯作者：
Baker, Philip N.