Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography (2019-2022).
Recent applications and chiral separation development based on stationary phases in open tubular capillary electrochromatography (2019-2022).
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DOI：
10.1016/j.jpha.2023.01.003
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发表时间：
2023-04
影响因子：
8.8
通讯作者：
Sun, Xiaodong
中科院分区：
文献类型：
--
作者：
Li, Xinyu;Ma, Qianjie;Zheng, Xiangtai;Chen, Qin;Sun, Xiaodong
关键词：
毛细管电色谱（CEC）通过双重分离原理、两相分配系数差异和电渗透流驱动分离在手性分离中发挥重要作用。由于内壁固定相（SP）具有不同的性质，因此每种固定相的分离能力各不相同。特别是，它为开管毛细管电色谱（OT-CEC）的应用提供了广阔的空间。我们将过去四年发展起来的OT-CEC SPs分为离子液体、纳米颗粒材料、微孔材料、生物材料、非纳米聚合物等六种类型，主要介绍它们在手性药物分离中的特点。本文还补充了近十年来出现的几种经典SP，丰富了每种SP的特点。此外，我们还讨论了它们在代谢组学、食品、化妆品、环境和生物学等方面的应用，以及作为手性药物的分析物。OT-CEC在手性分离中发挥着越来越重要的作用，并可能促进近年来毛细管电泳（CE）与质谱（CE/MS）和紫外检测器（CE/UV）等其他仪器相结合的发展。开管毛细管电色谱手性分离固定相研究进展。金属有机骨架；共价有机骨架；纳米颗粒;分子印迹材料。毛细管电泳-质谱法。
Capillary electrochromatography (CEC) plays a significant role in chiral separation via the double separation principle, partition coefficient difference between the two phases, and electroosmotic flow-driven separation. Given the distinct properties of the inner wall stationary phase (SP), the separation ability of each SP differs from one another. Particularly, it provides large room for promising applications of open tubular capillary electrochromatography (OT-CEC). We divided the OT-CEC SPs developed over the past four years into six types: ionic liquids, nanoparticle materials, microporous materials, biomaterials, non-nanopolymers, and others, to mainly introduce their characteristics in chiral drug separation. There also added a few classic SPs that occurred within ten years as supplements to enrich the features of each SP. Additionally, we discuss their applications in metabolomics, food, cosmetics, environment, and biology as analytes in addition to chiral drugs. OT-CEC plays an increasingly significant role in chiral separation and may promote the development of capillary electrophoresis (CE) combined with other instruments in recent years, such as CE with mass spectrometry (CE/MS) and CE with ultraviolet light detector (CE/UV). Recent advanced stationary phases for chiral separation in open tubular capillary electrochromatography. Metal organic frameworks; covalent organic frameworks; nanoparticles; molecularly imprinted materials. Capillary electrophoresis - mass spectrometry.
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