Mechanisms of Action of Carbapenem Resistance.
Mechanisms of Action of Carbapenem Resistance.
复制标题
DOI：
10.3390/antibiotics11030421
复制
发表时间：
2022-03-21
期刊：
影响因子：
--
通讯作者：
Pace MC
中科院分区：
文献类型：
--
作者：
Aurilio C;Sansone P;Barbarisi M;Pota V;Giaccari LG;Coppolino F;Barbarisi A;Passavanti MB;Pace MC
碳青霉烯类抗生素是治疗由最耐药细菌引起的感染最有效的抗菌剂。它们属于β-内酰胺类，包括青霉素类、头孢菌素类、单孢菌素类和碳青霉烯类。这类抗菌剂比大多数其他β -内酰胺类抗生素具有更广泛的活性，对革兰氏阳性和革兰氏阴性细菌最有效。所有β-内酰胺类抗生素都具有相似的分子结构：碳青霉烯类和β-内酰胺类。这种组合使分子具有非凡的稳定性，可以抵抗使β-内酰胺失活的酶。它们的使用是安全的，因此在许多国家的广泛使用引起了碳青霉烯耐药性，这是一个重大的全球公共卫生问题。某些物种的碳青霉烯耐药是内在的，包括通过几种机制抵抗抗生素作用的能力：由于缺乏特定靶点，或细胞质膜组成的内在差异或无法穿过外膜。除了内在耐药性外，细菌还可以通过几种机制对抗生素产生耐药性，这些机制可以分为三大类。第一类包括对细菌外膜渗透性差或抗生素外排的抗生素。第二种包括通过基因突变或翻译后修饰靶标来修饰抗生素靶标的细菌。第三种是通过酶催化修饰作用的细菌这是由于β -内酰胺酶的产生，它能够灭活碳青霉烯类，也就是所谓的碳青霉烯酶。本文就碳青霉烯的作用方式及耐药机制作一综述。
Carbapenem antibiotics are the most effective antimicrobials for the treatment of infections caused by the most resistant bacteria. They belong to the category of β-lactams that include the penicillins, cephalosporins, monobactams and carbapenems. This class of antimicrobials has a broader spectrum of activity than most other beta-lactams antibiotics and are the most effective against Gram-positive and Gram-negative bacteria. All β-lactams antibiotics have a similar molecular structure: the carbapenems together with the β-lactams. This combination gives an extraordinary stability to the molecule against the enzymes inactivating the β-lactams. They are safe to use and therefore widespread use in many countries has given rise to carbapenem resistance which is a major global public health problem. The carbapenem resistance in some species is intrinsic and consists of the capacity to resist the action of antibiotics with several mechanisms: for the absence of a specific target, or an intrinsic difference in the composition of cytoplasmatic membrane or the inability to cross the outer membrane. In addition to intrinsic resistance, bacteria can develop resistance to antibiotics with several mechanisms that can be gathered in three main groups. The first group includes antibiotics with poor penetration into the outer membrane of bacterium or antibiotic efflux. The second includes bacteria that modify the target of the antibiotics through genetic mutations or post-translational modification of the target. The third includes bacteria that act with enzyme-catalyzed modification and this is due to the production of beta-lactamases, that are able to inactivate carbapenems and so called carbapenemases. In this review, we focus on the mode of action of carbapenem and the mechanisms of carbapenem resistance.
登录
查看更多内容
影响因子：
11.8
作者：
Cuzon G;Naas T;Truong H;Villegas MV;Wisell KT;Carmeli Y;Gales AC;Venezia SN;Quinn JP;Nordmann P
通讯作者：
Nordmann P
控制亚胺培南耐药鲍曼不动杆菌及其耐药机制的干预措施的影响：一项为期 8 年的调查
影响因子：
5.2
作者：
Chen L;Tan P;Zeng J;Yu X;Cai Y;Liao K;Guo P;Chen Y;Wu Z;Qu P;Cai R;Chen C;Huang B
通讯作者：
Huang B
影响因子：
3.9
作者：
Ghai I;Ghai S
通讯作者：
Ghai S
影响因子：
4.9
作者：
Leavitt, Azita;Chmelnitsky, Inna;Navon-Venezia, Shiri
通讯作者：
Navon-Venezia, Shiri
DOI：
10.1126/science.1220761
发表时间：
2012-08-31
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Forsberg KJ;Reyes A;Wang B;Selleck EM;Sommer MO;Dantas G
通讯作者：
Dantas G