Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.
Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.
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DOI：
10.1038/s41467-021-21004-x
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发表时间：
2021-01-29
影响因子：
16.6
通讯作者：
Watanabe S
中科院分区：
文献类型：
--
作者：
Li S;Raychaudhuri S;Lee SA;Brockmann MM;Wang J;Kusick G;Prater C;Syed S;Falahati H;Ramos R;Bartol TM;Hosy E;Watanabe S
神经递质在动作电位后同步和异步释放。我们最近的研究表明，这两个阶段的释放位点分离的活动区，与异步释放位点附近的中心富集在小鼠海马突触。在这里，我们表明，同步和异步释放网站对齐AMPA受体和NMDA受体簇，分别。计算模拟表明，这种释放的空间和时间安排可以通过AMPA受体导致最大的膜去极化，减轻孔阻塞镁导致NMDA受体的更大激活。总之，这些结果表明，释放网站可能组织有效地激活NMDA受体。动作电位诱导神经递质的同步和异步释放。在这里，作者表明，同步和异步释放位点分别与小鼠海马突触中的AMPAR和NMDAR对齐。该组织允许有效激活NMDAR。
Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently. Action potentials induce synchronous and asynchronous release of neurotransmitters. Here, the authors show that the synchronous and asynchronous release sites are aligned with AMPARs and NMDARs, respectively, in mouse hippocampal synapses. This organization allows efficient activation of NMDARs.
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影响因子：
25
作者：
Fredj, Naila Ben;Burrone, Juan
通讯作者：
Burrone, Juan
影响因子：
7.7
作者：
Bartol TM;Bromer C;Kinney J;Chirillo MA;Bourne JN;Harris KM;Sejnowski TJ
通讯作者：
Sejnowski TJ
影响因子：
16.2
作者：
Ishikawa, T;Sahara, Y;Takahashi, T
通讯作者：
Takahashi, T
影响因子：
64.8
作者：
BEKKERS, JM;STEVENS, CF
通讯作者：
STEVENS, CF
DOI：
10.1073/pnas.91.22.10380
发表时间：
1994-10-25
影响因子：
11.1
作者：
ALLEN, C;STEVENS, CF
通讯作者：
STEVENS, CF