Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation.
Blood Level of Inter-Alpha Inhibitor Proteins Distinguishes Necrotizing Enterocolitis From Spontaneous Intestinal Perforation.
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DOI：
10.1016/j.jpeds.2016.09.016
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发表时间：
2017-01
影响因子：
5.1
通讯作者：
Padbury, James
中科院分区：
文献类型：
--
作者：
Shah, Birju A.;Migliori, Alison;Kurihara, Itsuka;Sharma, Surendra;Lim, Yow-Pin;Padbury, James
检查患有坏死性小肠结肠炎（NEC）、自发性肠穿孔（SIP）和匹配对照的婴儿体内α间抑制蛋白（IaIp）的循环水平，以评估 IaIp 区分 NEC 和 SIP 的诊断准确性；并将 NEC 的 IaIp 的接受者操作特征 (ROC) 与 C 反应蛋白 (CRP) 进行比较。对喂养不耐受婴儿进行了一项前瞻性、巢式病例对照研究。血液和临床数据收集自我们科室收治的 27 名诊断为 NEC 或 SIP 的婴儿以及 26 名匹配的对照婴儿。具有改良贝尔标准第 2 阶段或更高阶段的婴儿被纳入为 NEC。临床、放射学和/或手术结果用于识别患有 SIP 的婴儿。对照组的胎龄、产后年龄、性别和出生体重相匹配。 NEC、SIP和匹配对照婴儿的平均±SD IaIp血液水平分别为147±38 mg/L、276±67 mg/L和330±100 mg/L（P<0.004和P<0.01）。建立 NEC 预测值的 ROC 分析表明 IaIp 和 CRP 的曲线下面积分别为 0.98 和 0.63。与 SIP 和匹配对照相比，NEC 婴儿的 IaIp 水平显着降低。 IaIp 对 NEC 的诊断准确性优于 CRP。
To examine circulating levels of inter-alpha inhibitor protein (IaIp) in infants with necrotizing enterocolitis (NEC), spontaneous intestinal perforation (SIP) and matched controls in order to assess the diagnostic accuracy of IaIp to differentiate NEC from SIP; and to compare receiver operating characteristics (ROC) of IaIp for NEC with C-reactive protein (CRP). A p rospective, nested case control study of infants with feeding intolerance was carried out. Blood and clinical data were collected from 27 infants diagnosed with NEC or SIP and from 26 matched controls admitted to our unit. Infants with modified Bell's criteria stage 2 or higher were included as NEC. Clinical, radiological and/or surgical findings were used to identify infants with SIP. Controls were matched for gestational age, postnatal age, sex, and birth weight. Mean±SD IaIp blood levels were 147±38 mg/L, 276±67 mg/L and 330±100 mg/L in infants with NEC, SIP and matched controls, respectively (P<0.004 and P<0.01). ROC analysis to establish the predictive value of NEC demonstrated areas under curve of 0.98 and 0.63 for IaIp and CRP, respectively. IaIp levels were significantly decreased in infants with NEC compared with SIP and matched controls. The diagnostic accuracy of IaIp for NEC was superior to that of CRP.
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影响因子：
8
作者：
Kelleher, John;Salas, Ariel A.;Carlo, Waldemar A.
通讯作者：
Carlo, Waldemar A.
影响因子：
4.4
作者：
Garantziotis, Stavros;Hollingsworth, John W.;Schwartzt, David A.
通讯作者：
Schwartzt, David A.
影响因子：
2.9
作者：
Attridge, J. T.;Clark, R.;Gordon, P. V.
通讯作者：
Gordon, P. V.
影响因子：
5.1
作者：
Rabinowitz, SS;Dzakpasu, P;Kornecki, E
通讯作者：
Kornecki, E
DOI：
10.1056/nejmra1005408
发表时间：
2011-01-20
期刊：
The New England journal of medicine
影响因子：
--
作者：
Neu J;Walker WA
通讯作者：
Walker WA