Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease.
Neuropsychiatric symptoms associated multimodal brain networks in Alzheimer's disease.
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DOI：
10.1002/hbm.26051
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发表时间：
2023-01
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
--
作者：
伴随的神经精神症状（NST）与阿尔茨海默病（AD）的加速进展有关。识别与AD相关的多模态脑成像模式可能有助于理解AD相关的病理生理学。基于AD连续体，使用监督学习策略通过使用AD总分作为参考来指导四向多模态神经成像融合（淀粉样蛋白、Tau、灰质体积、脑功能）。在AD连续体中比较了所识别的多模态模式的负载。然后进行回归分析，探讨其预测纵向认知绩效。此外，融合分析重复的四个亚综合征。在这里，在额叶-皮质下边缘回路、枕叶和感觉运动区观察到了与神经元相关的病理-结构-功能共变模式。这种多模态模式的负荷随着AD的发展而逐渐增加。该模式与多个认知领域显着相关，也可以预测纵向认知下降。值得注意的是，使用子综合征作为参考的重复融合分析识别出了与不同综合征相关的一些独特变化的相似模式。总之，脑卒中与涉及复杂神经病理学的多模态成像模式相关，这可以有效预测纵向认知能力下降。这些结果突出了AD中神经递质的可能神经底物，这可能为临床管理提供指导。神经精神症状（Neuropsychiatric symptoms，NMPs）相关的多模态模式在空间上涉及额叶-皮质下边缘系统回路，其与认知表现和进展显著相关。不同的额叶-皮质下边缘回路区域在阿尔茨海默病患者中遭受不同的致病机制。在神经精神亚综合征中确定的亚综合征特异性模式。
Concomitant neuropsychiatric symptoms (NPS) are associated with accelerated Alzheimer's disease (AD) progression. Identifying multimodal brain imaging patterns associated with NPS may help understand pathophysiology correlates AD. Based on the AD continuum, a supervised learning strategy was used to guide four‐way multimodal neuroimaging fusion (Amyloid, Tau, gray matter volume, brain function) by using NPS total score as the reference. Loadings of the identified multimodal patterns were compared across the AD continuum. Then, regression analyses were performed to investigate its predictability of longitudinal cognition performance. Furthermore, the fusion analysis was repeated in the four NPS subsyndromes. Here, an NPS‐associated pathological–structural–functional covaried pattern was observed in the frontal‐subcortical limbic circuit, occipital, and sensor‐motor region. Loading of this multimodal pattern showed a progressive increase with the development of AD. The pattern significantly correlates with multiple cognitive domains and could also predict longitudinal cognitive decline. Notably, repeated fusion analysis using subsyndromes as references identified similar patterns with some unique variations associated with different syndromes. Conclusively, NPS was associated with a multimodal imaging pattern involving complex neuropathologies, which could effectively predict longitudinal cognitive decline. These results highlight the possible neural substrate of NPS in AD, which may provide guidance for clinical management. Neuropsychiatric symptoms (NPS)‐associated multimodal pattern spatially involves frontal‐subcortical limbic circuits, which significantly associated with cognitive performance and progression. Different frontal‐subcortical limbic circuit regions suffer different pathogenic mechanisms in Alzheimer's disease subjects concomitant with NPS. Subsyndrome‐specific patterns identified among neuropsychiatric subsyndromes.
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影响因子：
9.9
作者：
Cummings, JL
通讯作者：
Cummings, JL
DOI：
10.1176/appi.ajp.2014.14040480
发表时间：
2015-05
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Peters ME;Schwartz S;Han D;Rabins PV;Steinberg M;Tschanz JT;Lyketsos CG
通讯作者：
Lyketsos CG
DOI：
10.3233/jad-2010-1237
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Jicha GA;Carr SA
通讯作者：
Carr SA
影响因子：
3.7
作者：
Mormino, Elizabeth C.;Smiljic, Andre;Jagust, William J.
通讯作者：
Jagust, William J.
影响因子：
2.4
作者：
Aalten, Pauline;Verhey, Frans R. J.;Robert, Philippe H.
通讯作者：
Robert, Philippe H.