Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer.
Zhx2 and Zbtb20: novel regulators of postnatal alpha-fetoprotein repression and their potential role in gene reactivation during liver cancer.
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DOI：
10.1016/j.semcancer.2011.01.001
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发表时间：
2011-02
影响因子：
14.5
通讯作者：
Spear BT
中科院分区：
文献类型：
--
作者：
Peterson ML;Ma C;Spear BT
小鼠甲胎蛋白（AFP）基因在胎儿肝脏中大量表达，在成人肝脏中通常沉默，但在肝细胞癌中经常被重新激活。胎儿肝脏中AFP表达的基础已被广泛研究。然而，肝癌发生过程中AFP再激活的基础尚不清楚。最近发现了两个控制出生后AFP抑制的新因子，Zhx2和Zbtb20。在这里，我们回顾了在胎儿肝脏中调节AFP的转录因子，以及Zhx2和Zbtb20，并提出这些出生后抑制因子的缺失可能参与了肝癌中AFP再激活的可能性。
The mouse alpha-fetoprotein (AFP) gene is abundantly expressed in the fetal liver, normally silent in the adult liver but is frequently reactivated in hepatocellular carcinoma. The basis for AFP expression in the fetal liver has been studied extensively. However, the basis for AFP reactivation during hepatocarcinogenesis is not well understood. Two novel factors that control postnatal AFP repression, Zhx2 and Zbtb20, were recently identified. Here, we review the transcription factors that regulate AFP in the fetal liver, as well as Zhx2 and Zbtb20, and raise the possibility that the loss of these postnatal repressors may be involved in AFP reactivation in liver cancer.
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