Translational approaches to treatment-induced symptoms in cancer patients.
Translational approaches to treatment-induced symptoms in cancer patients.
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DOI：
10.1038/nrclinonc.2012.88
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发表时间：
2012-05-29
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影响因子：
--
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--
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癌症治疗使病人生病。临床医生可用的治疗方法使他们能够成功地控制恶心、呕吐和疼痛。然而，对于其他一些症状，包括疲劳、注意力不集中、记忆力差、对先前愉快的活动失去兴趣等，情况并非如此。这些症状在癌症治疗过程中聚集，损害患者的生活质量，限制治疗选择，并且在停止治疗时并不总是消失。有可能描述症状的强度和时间特征，并评估它们与癌症和癌症治疗相关的炎症反应的关系。在临床前水平，仍需要建立复杂的动物模型来研究炎症在癌症相关症状的特定组成部分中的因果作用。各种方法可以在转化症状研究途径中最佳地结合，为系统地评估现有和新开发的癌症治疗的神经行为毒性提供框架。最终，这一知识将允许衍生基于机制的干预措施，以预防或减轻癌症相关症状。
Cancer therapy makes patients sick. The therapies that are available to clinicians allow them to successfully control nausea, emesis, and pain. However, this is not the case for a number of other symptoms that include fatigue, distractibility, poor memory, and diminished interest in previously pleasurable activities. These symptoms cluster during the course of cancer therapy and impair patient quality of life, limit therapy options, and do not always resolve at the cessation of treatment. It is possible to describe the intensity and temporal features of symptoms and assess their relationship with the inflammatory response that is associated with cancer and cancer therapy. At the preclinical level, sophisticated animal models still need to be deployed to study the causal role of inflammation in specific components of cancer-related symptoms. Various approaches can be optimally combined in a translational symptom research pathway to provide a framework for assessing in a systematic manner the neurobehavioral toxicity of existing and newly developed cancer therapies. Ultimately this knowledge will allow derivation of mechanism-based interventions to prevent or alleviate cancer-related symptoms.
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