Natural plant products in treatment of pulmonary arterial hypertension.
Natural plant products in treatment of pulmonary arterial hypertension.
复制标题
天然植物产品治疗肺动脉高压
DOI：
10.1177/2045894018784033
复制
发表时间：
2018-07
影响因子：
2.6
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Xiang L;Li Y;Deng X;Kosanovic D;Schermuly RT;Li X
肺动脉高压（PAH）是一种以肺动脉远端进行性重构和肺血管阻力（PVR）持续升高为特征的严重疾病，可导致右心室功能障碍、心力衰竭，最终导致死亡。虽然对这种疾病的治疗反应正在改善，但它仍然是一种危及生命的疾病。随着天然植物产品的临床疗效被多年的实践所充分证实，越来越得到国际医药业界的认可和重视。此外，几十年来的研究表明，天然植物衍生药物在治疗多环芳烃方面具有独特的优势和广阔的应用前景，更不用说中药在心肺疾病方面的历史应用了。本文将对多环芳烃中具有治疗作用的天然植物化合物进行综述，并按植物提取物、组分和纯化合物进行分类，以期对基础研究和临床应用有所帮助。
Pulmonary arterial hypertension (PAH) is a severe disease characterized by progressive remodeling of distal pulmonary arteries and persistent elevation of pulmonary vascular resistance (PVR), which leads to right ventricular dysfunction, heart failure, and eventually death. Although treatment responsiveness for this disease is improving, it continues to be a life-threatening condition. With the clinical efficacy of natural plant products being fully confirmed by years of practice, more and more recognition and attention have been obtained from the international pharmaceutical industry. Moreover, studies over the past decades have demonstrated that drugs derived from natural plants show unique advantages and broad application prospects in PAH treatment, not to mention the historical application of Chinese traditional medicine in cardiopulmonary diseases. In this review, we focus on summarizing natural plant compounds with therapeutic properties in PAH, according to the extracts, fractions, and pure compounds from plants into categories, hoping it to be helpful for basic research and clinical application.
登录
查看更多内容
影响因子：
5.3
作者：
Chen, Jia-Shiong;Huang, Po-Hsun;Chen, Jaw-Wen
通讯作者：
Chen, Jaw-Wen
影响因子：
5
作者：
Chen, Wenying;Tang, Futian;Liu, Peiqing
通讯作者：
Liu, Peiqing
影响因子：
3
作者：
Bayar, MA;Erdem, Y;Üstün, H
通讯作者：
Üstün, H
影响因子：
3.7
作者：
Chen C;Chen C;Wang Z;Wang L;Yang L;Ding M;Ding C;Sun Y;Lin Q;Huang X;Du X;Zhao X;Wang C
通讯作者：
Wang C
影响因子：
3.4
作者：
Chen, Changgui;Tang, Yanhong;Wu, Tianyi
通讯作者：
Wu, Tianyi