Relationship between Otitis Media and Epithelial Function in the Lymphoepithelium of Pediatric Adenoids.
Relationship between Otitis Media and Epithelial Function in the Lymphoepithelium of Pediatric Adenoids.
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中耳炎与小儿腺样体淋巴细胞上皮功能的关系。
DOI：
10.1159/000441868
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Himi T.
中科院分区：
文献类型：
--
作者：
Ogasawara N;Yamamoto K;Takano K;Himi T.
鼻或鼻咽相关淋巴组织（NALT）具有不同于其他淋巴组织的独特作用。在上呼吸道黏膜免疫应答过程中，NALT诱导多种应答，包括细胞因子和趋化因子的产生以及天然免疫应答，以建立获得性免疫。NALT由上皮细胞、上皮相关淋巴组织如IgA定型B细胞、先天性淋巴细胞、T辅助细胞和树突状细胞组成。鼻内免疫最近已显示除了全身免疫应答之外，还有效地诱导局部粘膜中的主动免疫应答。多种因素可引起中耳炎，包括咽鼓管功能障碍、炎症、过敏以及病毒和细菌感染。然而，中耳炎的详细发病机制尚未完全了解。在这份报告中，我们提供的证据表明，腺样组织作为NALT的一个组成部分，在儿童病毒感染后诱导先天免疫可能发挥重要作用。
Nose-or nasopharynx-associated lymphoid tissue (NALT) has a unique role that is distinct from that of other lymphoid tissues. During upper airway mucosal immune response, NALT induces a variety of responses, including cytokine and chemokine production and innate immune response, to establish acquired immunity. NALT consists of epithelial cells, epithelium-associated lymphoid tissues such as IgA-committed B cells, innate lymphocytes, T helper cells and dendritic cells. Intranasal immunization has recently been shown to effectively induce a proactive immune response in the local mucosa in addition to a systemic immune response. A variety of factors can cause otitis media, including Eustachian tube dysfunction, inflammation, allergy and viral and bacterial infections. However, the detailed pathogenesis of otitis media is not yet completely understood. In this report, we provide evidence suggesting that adenoid tissue as a component of NALT in children may play an important role in inducing innate immunity following viral infection.
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影响因子：
10.8
作者：
Rajapaksa, Thejani E.;Stover-Hamer, Mary;Fernandez, Xiomara;Eckelhoefer, Holly A.;Lo, David D.
通讯作者：
Lo, David D.
影响因子：
30.5
作者：
Sheppard, P;Kindsvogel, W;Klucher, KM
通讯作者：
Klucher, KM
DOI：
--
发表时间：
1990
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Faden,H;Stanievich,J;Brodsky,L;Bernstein,J;Ogra,PL
通讯作者：
Ogra,PL
影响因子：
5.2
作者：
Hidehiko Suzuki;M. Kondoh;A. Takahashi;K. Yagi
通讯作者：
Hidehiko Suzuki;M. Kondoh;A. Takahashi;K. Yagi
普通感冒和中耳炎的细胞因子反应
影响因子：
5.5
作者：
T. Wine;C. Alper
通讯作者：
C. Alper