Cytokine Responses in the Common Cold and Otitis Media
Cytokine Responses in the Common Cold and Otitis Media
复制标题
普通感冒和中耳炎的细胞因子反应
DOI：
--
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发表时间：
2012
影响因子：
5.5
通讯作者：
C. Alper
中科院分区：
文献类型：
--
作者：
T. Wine;C. Alper
细胞因子是一组影响每个器官系统功能的不同分子。它们在对免疫系统的影响及其在介导炎症中的整体作用方面研究得最充分。普通感冒和中耳炎是两种这样的疾病状态，并且已经了解了许多关于细胞因子在每种疾病中的各种作用。最常见的病毒包括鼻病毒（RV）、呼吸道合胞病毒（RSV）、腺病毒、冠状病毒和小核糖核酸病毒。中耳炎、鼻窦炎、细支气管炎、肺炎和哮喘恶化通常被认为是病毒性上呼吸道感染的并发症。此外，中耳炎和上呼吸道感染不可分割地联系在一起，因为大多数（> 70%）急性中耳炎病例作为普通感冒的并发症发生。细胞因子多态性与感冒的严重程度以及中耳炎的频率有关。这篇文章试图更新读者对各种研究，最近发表的关于细胞因子在这两种疾病实体的作用。
Cytokines are a group of diverse molecules that influence the function of every organ system. They are most well studied in their effects on the immune system and their integral role in mediating inflammation. The common cold and otitis media are two such disease states, and much has been learned about the various effects of cytokines in each disease. Most often the viruses isolated include rhinovirus (RV), respiratory syncytial virus (RSV), adenovirus, coronavirus, and picornavirus. Otitis media, sinusitis, bronchiolitis, pneumonia, and asthma exacerbation are commonly accepted as complications of viral upper respiratory tract infections. Furthermore, otitis media and upper respiratory infections are inextricably linked in that the majority (>70 %) of cases of acute otitis media occur as complications of the common cold. Cytokine polymorphisms have been associated with the severity of colds as well as the frequency of otitis media. This article attempts to update the reader on various studies that have recently been published regarding the role of cytokines in these two disease entities.
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影响因子：
--
作者：
Segade, Fernando;Daly, Kathleen A.;Bowden, Donald W.
通讯作者：
Bowden, Donald W.
影响因子：
120.7
作者：
Casselbrant, ML;Mandel, EM;Ferrell, RE
通讯作者：
Ferrell, RE
DOI：
10.1086/599833
发表时间：
2009-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Revai K;Patel JA;Grady JJ;Nair S;Matalon R;Chonmaitree T
通讯作者：
Chonmaitree T
呼吸道合胞病毒在急性中耳炎中的作用：对疫苗开发的影响。
影响因子：
5.5
作者：
Patel,JanakA;Nguyen,DangT;Revai,Krystal;Chonmaitree,Tasnee
通讯作者：
Chonmaitree,Tasnee