Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature.
Metastasis of breast cancer to an endometrial polyp, the cervix and a leiomyoma: A case report and review of the literature.
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DOI：
10.3892/ol.2017.6822
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发表时间：
2017-10
期刊：
影响因子：
2.9
通讯作者：
Kyo S
中科院分区：
文献类型：
--
作者：
Razia S;Nakayama K;Tsukao M;Nakamura K;Ishikawa M;Ishibashi T;Ishikawa N;Sanuki K;Yamashita H;Ono R;Hossain MM;Minamoto T;Kyo S
先前已证明乳腺癌肿瘤的血行转移经常发生在肺、骨、肝和脑的部位，然而在子宫中的存在仍然是罕见的。转移性子宫癌通常起源于其他生殖器部位，最常见的是卵巢。目前的审查提出了第一个报告的情况下，小叶乳腺癌转移到子宫内膜息肉，子宫颈和平滑肌瘤同时。患者（58岁，女性）首次出现异常子宫出血。浸润性导管癌以前曾被诊断为在她的右乳房，小叶和导管癌细胞观察到存在于她的淋巴结。宫腔镜检查绝经后出血发现子宫内膜息肉，随后切除。形态学和免疫组化研究证实了乳腺小叶癌转移到子宫内膜息肉的诊断。诊断后进行的18F氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET-CT）显示肌瘤中的摄取略有增加，这通常在良性子宫肌瘤中观察到。然后，患者接受了全腹子宫切除术，双侧输卵管卵巢切除术和部分结肠切除术。病理结果显示子宫平滑肌瘤及子宫颈与原发性小叶癌具有相同的组织病理学特征。虽然罕见，乳腺肿瘤可能转移到子宫内膜息肉，子宫颈和平滑肌瘤同时在患者中，因此，医生现在可能会考虑诊断转移到生殖道的可能性，在异常子宫出血和小叶乳腺癌病史的患者中。计划对有小叶乳腺癌病史的患者进行腹腔镜子宫切除术的妇科医生可能会考虑经腹而不是腹腔镜子宫切除术，因为小叶癌很难被发现。PET-CT的使用可能有助于识别意外肿块。
Haematogenous metastases of breast cancer tumors has previously been demonstrated to frequently occur at the sites of the lung, bones, liver and brain, however presence in the uterine remains a rare occurrence. Metastatic carcinoma of the uterus usually originates from other genital sites, most frequently from the ovaries. The current review presents the first reported case of lobular breast carcinoma metastasizing to an endometrial polyp, the cervix and a leiomyoma simultaneously. The patient (58 years, female) first presented with abnormal uterine bleeding. Invasive ductal carcinoma had previously been diagnosed in her right breast, with lobular and ductal cancer cells observed to be present in her lymph nodes. A hysteroscopic procedure to examine the postmenopausal bleeding revealed an endometrial polyp, which was subsequently resected. The morphology and immunohistochemical studies confirmed the diagnosis of metastasis of lobular breast carcinoma to an endometrial polyp. An 18F fludeoxyglucose positron emission tomography/computed tomography (PET-CT) scan performed following the diagnosis, revealed a slightly increased uptake in the myoma, which is often observed in benign uterine leiomyoma. The patient then underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy and partial colectomy. Pathology results demonstrated that the uterine leiomyoma and cervix shared the same histopathological features as those presented by the primary lobular breast carcinoma. Although rare, breast tumors may metastasize to an endometrial polyp, cervix and leiomyoma concurrently in patients, therefore physicians may now consider the potential of the diagnosis of metastatic spread to the genital tract, in a patient with abnormal uterine bleeding and a history of lobular breast cancer. Gynecologists planning a laparoscopic hysterectomy for a patient with a history of lobular breast carcinoma may consider abdominal rather than laparoscopic hysterectomy, as lobular carcinoma is difficult to detect. The use of PET-CT may be beneficial for the identification of an unexpected mass.
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影响因子：
4.7
作者：
Acikalin, MF;Öner, Ü;Cengiz, O
通讯作者：
Cengiz, O
DOI：
10.1016/0002-9378(71)90789-7
发表时间：
1971-01-01
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作者：
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影响因子：
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作者：
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